Outbreak of severe community-acquired bacterial infections among children in North Rhine-Westphalia (Germany), October to December 2022.

Autor: Goretzki SC; Department of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., van der Linden M; German Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany., Itzek A; German Reference Laboratory for Streptococci, Department of Medical Microbiology, University Hospital RWTH Aachen, Aachen, Germany., Hühne T; Department of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Adelmann RO; Department of General Pediatrics, Klinikum Oberberg, Kreiskrankenhaus Gummersbach, Gummersbach, Germany., Ala Eldin F; Department of General Pediatrics, Helios Hospital Schwelm, Schwelm, Germany., Albarouni M; Department of General Pediatrics, Marien-Hospital Gelsenkirchen, Gelsenkirchen, Germany., Becker JC; Department of Pediatrics, Agaplesion Hospital Hagen, Hagen, Germany., Berghäuser MA; Division of Pediatric Intensive Care, Department of Pediatrics, Florence Nightingale Hospital Kaiserswerth, Düsseldorf, Germany., Boesing T; Division of Pediatric Intensive Care, Department of Pediatrics, Protestant Hospital Bethel, University of Bielefeld, Bielefeld, Germany., Boeswald M; Department of Pediatrics, Sankt Franziskus Hospital Münster, Münster, Germany., Brasche M; Division of Neonatology, Department of Pediatrics, University Hospital, RWTH University of Aachen, Aachen, Germany., Brevis Nuñez F; Division of Pediatric Intensive Care, Department of Pediatrics, Sana Hospitals Duisburg, Duisburg, Germany., Camara R; Division of Neonatology, Department of Pediatrics and Adolescent Medicine, GFO Hospital Bonn, Bonn, Germany., Deibert C; Department of General Pediatrics, DRK Hospital Kirchen, Kirchen, Germany., Dohle F; Department of Pediatrics, Pediatric Intensive Care Medicine, St. Vinzenz Hospital Paderborn, Paderborn, Germany., Dolgner J; Department of General Pediatrics, GFO Hospital Dinslaken, Dinslaken, Germany., Dziobaka J; Department of Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Eifinger F; Division of Pediatric Intensive Care, Department of Pediatrics, University Hospital, University of Cologne, Cologne, Germany., Elting N; Department of General Pediatrics, Evangelical Hospital Oberhausen, Oberhausen, Germany., Endmann M; Department of General Pediatrics, St. Franziskus-Hospital Ahlen, Ahlen, Germany., Engelmann G; Department of General Pediatrics, Lukas-Hospital Neuss, Neuss, Germany., Frenzke H; Department of General Pediatrics, Märkisch Hospital Lüdenscheid, Lüdenscheid, Germany., Gappa M; Department of General Pediatrics, Evangelical Hospital Düsseldorf, Düsseldorf, Germany., Gharavi B; Department of General Pediatrics, Marien-Hospital Witten, Witten, Germany., Goletz C; Department of General Pediatrics, Städtische Kliniken Mönchengladbach, Elisabeth-Hospital Rheydt, Mönchengladbach, Germany., Hahn E; Department of Pediatrics and Adolescent Medicine, Sankt Agnes Hospital, Bocholt, Germany., Heidenreich Y; Department of General Pediatrics, Hospital Soest gGmbH, Soest, Germany., Heimann K; Division of Neonatology, Department of Pediatrics, University Hospital, RWTH University of Aachen, Aachen, Germany., Hensel KO; Division of Pediatric Intensive Care, Department of Pediatrics, Helios University Hospital Wuppertal, Witten/Herdecke University, Wuppertal, Germany., Hoffmann HG; Department of General Pediatrics, Mathias-Stiftung, Rheine, Germany., Hoppenz M; Division of Pediatric Intensive Care, Department of Pediatrics, Children's Hospital, Amsterdamer Str., Cologne, Germany., Horneff G; Department of Pediatrics, Asklepios Clinic Sankt Augustin GmbH, Sankt Augustin, Germany., Klassen H; Department of Pediatrics and Adolescent Medicine, Hochsauerland Hospital, Arnsberg, Germany., Koerner-Rettberg C; Department of General Pediatrics, Marien-Hospital gGmbH, Wesel, Germany., Längler A; Department of Pediatrics, Gemeinschaftskrankenhaus Herdecke, University of Witten/Herdecke, Herdecke, Germany., Lenz P; Department of General Pediatrics, Hospital Leverkusen GmbH, Leverkusen, Germany., Lohmeier K; Division of Neonatology and Pediatric Cardiology, Department of General Pediatrics, Heinrich Heine University, Düsseldorf, Germany., Müller A; Department of Neonatology and Pediatric Intensive Care Medicine, University of Bonn, Bonn, Germany., Niemann F; Department of General Pediatrics, Marien-Hospital Gelsenkirchen, Gelsenkirchen, Germany., Paulussen M; Division of Oncology and Haematology, Department of General Pediatrics, Hospital of Children and Adolescents, University of Witten/Herdecke, Datteln, Germany., Pentek F; Department of Pediatrics, Elisabeth-Hospital Essen, Essen, Germany., Perez R; Division of Pediatric Intensive Care, Department of Pediatrics, Helios Hospital Krefeld, Krefeld, Germany., Pingel M; Department of General Pediatrics, DRK Hospital Siegen gGmbH, Siegen, Germany., Repges P; Department of General Pediatrics, Porz, Cologne, Germany., Rothoeft T; Division of Neonatology and Pediatric Intensive Care, University Children's Hospital, Ruhr University of Bochum, Bochum, Germany., Rübo J; Department of General Pediatrics, St. Antonius Hospital Kleve, Kleve, Germany., Schade H; Department of General Pediatrics, Hospital Mechernich GmbH, Mechernich, Germany., Schmitz R; Department of Pediatrics, Helios Clinic Duisburg, Duisburg, Germany., Schonhoff P; Department of Pediatrics, Clemenshospital Münster, Münster, Germany., Schwade JN; Department of General Pediatrics, Evangelical Hospital Lippstadt, Lippstadt, Germany., Schwarz T; Department of General Pediatrics, Municipal Hospital Solingen, Solingen, Germany., Seiffert P; Department of Pediatrics, Helios Clinic Duisburg, Duisburg, Germany., Selzer G; Division of Neonatology and Pediatric Intensive Care, Evangelical Hospital Hamm, Hamm, Germany., Spille U; Department of General Pediatrics, Herford, Germany., Thiel C; Department of Pediatrics, St.-Clemens-Hospital Geldern, Geldern, Germany., Thimm A; Department of General Pediatrics, Sana-Hospital Remscheid, Remscheid, Germany., Urgatz B; Department of General Pediatrics, AKH Hospital Viersen, Viersen, Germany., van den Heuvel A; Division of Pediatric Intensive Care, Department of Pediatrics, University Hospital Münster, Münster, Germany., van Hop T; Department of General Pediatrics, Hospital Oberhausen Sterkrade gGmbH, Oberhausen, Germany., Giesen V; Department of General Pediatrics, Bethanien Hospital Moers, Moers, Germany., Wirth S; Department of Pediatrics, Helios Medical Center Niederberg, Velbert, Germany., Wollbrink T; Division of Pediatric Intensive Care, Department of Pediatrics, Bergmannsheil Pediatric Hospital Gelsenkirchen Buer, Gelsenkirchen, Germany., Wüller D; Department of Pediatrics and Adolescent Medicine, Christophorus Hospital, Coesfeld, Germany., Felderhoff-Müser U; Department of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Dohna-Schwake C; Department of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Lâm TT; German National Reference Laboratory for Meningococci and Haemophilus Influenzae, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany., Claus H; German National Reference Laboratory for Meningococci and Haemophilus Influenzae, Institute for Hygiene and Microbiology, University of Würzburg, Würzburg, Germany., Bruns N; Department of Pediatrics I (Neonatology, Pediatric Intensive Care, Pediatric Neurology, and Pediatric Infectious Diseases), University Hospital Essen, University of Duisburg-Essen, Essen, Germany. nora.bruns@uk-essen.de.
Jazyk: angličtina
Zdroj: Infection [Infection] 2024 Jun; Vol. 52 (3), pp. 1099-1111. Date of Electronic Publication: 2024 Feb 16.
DOI: 10.1007/s15010-023-02165-x
Abstrakt: Purpose: In late 2022, a surge of severe S. pyogenes infections was reported in several European countries. This study assessed hospitalizations and disease severity of community-acquired bacterial infections with S. pyogenes, S. pneumoniae, N. meningitidis, and H. influenzae among children in North Rhine-Westphalia (NRW), Germany, during the last quarter of 2022 compared to long-term incidences.
Methods: Hospital cases due to bacterial infections between October and December 2022 were collected in a multicenter study (MC) from 59/62 (95%) children's hospitals in NRW and combined with surveillance data (2016-2023) from the national reference laboratories for streptococci, N. meningitidis, and H. influenzae. Overall and pathogen-specific incidence rates (IR) from January 2016 to March 2023 were estimated via capture-recapture analyses. Expected annual deaths from the studied pathogens were calculated from national death cause statistics.
Results: In the MC study, 153 cases with high overall disease severity were reported with pneumonia being most common (59%, n = 91). IRs of bacterial infections declined at the beginning of the COVID-19 pandemic and massively surged to unprecedented levels in late 2022 and early 2023 (overall hospitalizations 3.5-fold), with S. pyogenes and S. pneumoniae as main drivers (18-fold and threefold). Observed deaths during the study period exceeded the expected number for the entire year in NRW by far (7 vs. 0.9).
Discussion: The unprecedented peak of bacterial infections and deaths in late 2022 and early 2023 was caused mainly by S. pyogenes and S. pneumoniae. Improved precautionary measures are needed to attenuate future outbreaks.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: