Tissue-specific roles of peroxisomes revealed by expression meta-analysis.

Autor: Plessner M; Department of Biochemistry and Molecular Medicine, Medical School OWL, Bielefeld University, Bielefeld, Germany., Thiele L; Department of Biochemistry and Molecular Medicine, Medical School OWL, Bielefeld University, Bielefeld, Germany., Hofhuis J; Department of Biochemistry and Molecular Medicine, Medical School OWL, Bielefeld University, Bielefeld, Germany., Thoms S; Department of Biochemistry and Molecular Medicine, Medical School OWL, Bielefeld University, Bielefeld, Germany. sven.thoms@uni-bielefeld.de.; Department of Child and Adolescent Health, University Medical Center, Göttingen, Germany. sven.thoms@uni-bielefeld.de.
Jazyk: angličtina
Zdroj: Biology direct [Biol Direct] 2024 Feb 16; Vol. 19 (1), pp. 14. Date of Electronic Publication: 2024 Feb 16.
DOI: 10.1186/s13062-024-00458-1
Abstrakt: Peroxisomes are primarily studied in the brain, kidney, and liver due to the conspicuous tissue-specific pathology of peroxisomal biogenesis disorders. In contrast, little is known about the role of peroxisomes in other tissues such as the heart. In this meta-analysis, we explore mitochondrial and peroxisomal gene expression on RNA and protein levels in the brain, heart, kidney, and liver, focusing on lipid metabolism. Further, we evaluate a potential developmental and heart region-dependent specificity of our gene set. We find marginal expression of the enzymes for peroxisomal fatty acid oxidation in cardiac tissue in comparison to the liver or cardiac mitochondrial β-oxidation. However, the expression of peroxisome biogenesis proteins in the heart is similar to other tissues despite low levels of peroxisomal fatty acid oxidation. Strikingly, peroxisomal targeting signal type 2-containing factors and plasmalogen biosynthesis appear to play a fundamental role in explaining the essential protective and supporting functions of cardiac peroxisomes.
(© 2024. The Author(s).)
Databáze: MEDLINE
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