Ambient air pollutants and breast cancer stage in Tehran, Iran.

Autor: Khorrami Z; Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Pourkhosravani M; Department of Geography and Urban Planning, Shahid Bahonar University of Kerman, Kerman, Iran., Karamoozian A; Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Jafari-Khounigh A; Road Traffic Injury Research Center, Tabriz University of Medical Sciences, Tabriz, Iran., Akbari ME; Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rezapour M; Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran., Khorrami R; Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran., Taghavi-Shahri SM; Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Amini H; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Institute for Climate Change, Environmental Health and Exposomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Etemad K; Cancer Research Center (CRC), Shahid Beheshti University of Medical Sciences, Tehran, Iran. etemadk@gmail.com., Khanjani N; Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El Paso, El Paso, TX, USA. nkhanjan@ttuhsc.edu.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 16; Vol. 14 (1), pp. 3873. Date of Electronic Publication: 2024 Feb 16.
DOI: 10.1038/s41598-024-53038-8
Abstrakt: This study aimed to examine the impacts of single and multiple air pollutants (AP) on the severity of breast cancer (BC). Data of 1148 diagnosed BC cases (2008-2016) were obtained from the Cancer Research Center and private oncologist offices in Tehran, Iran. Ambient PM 10 , SO 2 , NO, NO 2 , NO X , benzene, toluene, ethylbenzene, m-xylene, p-xylene, o-xylene, and BTEX data were obtained from previously developed land use regression models. Associations between pollutants and stage of BC were assessed by multinomial logistic regression models. An increase of 10 μg/m 3 in ethylbenzene, o-xylene, m-xylene, and 10 ppb of NO corresponded to 10.41 (95% CI 1.32-82.41), 4.07 (1.46-11.33), 2.89 (1.08-7.73) and 1.08 (1.00-1.15) increase in the odds of stage I versus non-invasive BC, respectively. Benzene (OR, odds ratio = 1.16, 95% CI 1.01-1.33) and o-xylene (OR = 1.18, 1.02-1.38) were associated with increased odds of incidence of BC stages III & IV versus non-invasive stages. BC stage I and stage III&IV in women living in low SES areas was associated with significantly higher levels of benzene, ethylbenzene, o-xylene, and m-xylene. The highest multiple-air-pollutants quartile was associated with a higher odds of stage I BC (OR = 3.16) in patients under 50 years old. This study provides evidence that exposure to AP is associated with increased BC stage at diagnosis, especially under premenopause age.
(© 2024. The Author(s).)
Databáze: MEDLINE
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