Can transcranial direct current stimulation combined with interactive computerized cognitive training boost cognition and gait performance in older adults with mild cognitive impairment? a randomized controlled trial.

Autor: Lau CI; Dementia Center, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; Applied Cognitive Neuroscience Group, Institute of Cognitive Neuroscience, University College London, London, UK.; Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan.; College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan., Liu MN; Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan.; Division of Psychiatry, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Cheng FY; Institute of Long-Term Care, MacKay Medical College, New Taipei, Taiwan., Wang HC; Dementia Center, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.; College of Medicine, National Taiwan University, Taipei, Taiwan., Walsh V; Applied Cognitive Neuroscience Group, Institute of Cognitive Neuroscience, University College London, London, UK., Liao YY; Department of Gerontological Health Care, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. ianliao1209@gmail.com.
Jazyk: angličtina
Zdroj: Journal of neuroengineering and rehabilitation [J Neuroeng Rehabil] 2024 Feb 16; Vol. 21 (1), pp. 26. Date of Electronic Publication: 2024 Feb 16.
DOI: 10.1186/s12984-024-01313-0
Abstrakt: Background: Older adults with Mild Cognitive Impairment (MCI) are often subject to cognitive and gait deficits. Interactive Computerized Cognitive Training (ICCT) may improve cognitive function; however, the effect of such training on gait performance is limited. Transcranial Direct Current Stimulation (tDCS) improves cognition and gait performance. It remains unclear whether combining tDCS with ICCT produces an enhanced synergistic effect on cognition and complex gait performance relative to ICCT alone. This study aimed to compare the effects of tDCS combined with ICCT on cognition and gait performance in older adults with MCI.
Method: Twenty-one older adults with MCI were randomly assigned to groups receiving either anodal tDCS and ICCT ( tDCS + ICCT ) or sham tDCS and ICCT ( sham + ICCT ). Participants played Nintendo Switch cognitive games for 40 min per session, simultaneously receiving either anodal or sham tDCS over the left dorsolateral prefrontal cortex for the first 20 min. Cognitive and gait assessments were performed before and after 15 training sessions.
Results: The global cognition, executive function, and working-memory scores improved in both groups, but there were no significant interaction effects on cognitive outcomes. Additionally, the group × time interactions indicated that tDCS + ICCT significantly enhanced dual-task gait performance in terms of gait speed (p = 0.045), variability (p = 0.016), and dual-task cost (p = 0.039) compared to sham + ICCT.
Conclusion: The combined effect of tDCS and ICCT on cognition was not superior to that of ICCT alone; however, it had a significant impact on dual-task gait performance. Administering tDCS as an adjunct to ICCT may thus provide additional benefits for older adults with MCI.
Trial Registration: This trial was registered at http://www.
Clinicaltrials: in.th/ (TCTR 20,220,328,009).
(© 2024. The Author(s).)
Databáze: MEDLINE
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