Irreversible electroporation: Beyond the limits of tumor ablation.

Autor: Alonso-González R; Radiología Vascular Intervencionista, Hospital Universitario Severo Ochoa, Madrid, Spain. Electronic address: rodro.a.g.c@gmail.com., Abadal Villayandre JM; Radiología Vascular Intervencionista, Hospital Universitario Severo Ochoa, Madrid, Spain., Gálvez Gonzalez E; Radiología Vascular Intervencionista, Hospital Universitario Severo Ochoa, Madrid, Spain., Álvarez Perez MJ; Radiología Vascular Intervencionista, Hospital Universitario Severo Ochoa, Madrid, Spain., Méndez Alonso S; Radiología Vascular Intervencionista, Hospital Universitario Puerta Hierro, Madrid, Spain., de Gregorio Ariza MA; Radiología Vascular Intervencionista, Clínica Quirón, Zaragoza, Spain.
Jazyk: angličtina
Zdroj: Radiologia [Radiologia (Engl Ed)] 2024 Jan-Feb; Vol. 66 (1), pp. 47-56. Date of Electronic Publication: 2023 Jun 26.
DOI: 10.1016/j.rxeng.2023.04.002
Abstrakt: Irreversible Electroporation (IRE) is a non-thermal tumor ablation technique. High-voltage electrical pulses are applied between pairs of electrodes inserted around and/or inside a tumor. The generated electric current induces the creation of nanopores in the cell membrane, triggering apoptosis. As a result, IRE can be safely used in areas near delicate vascular structures where other thermal ablation methods are contraindicated. Currently, IRE has demonstrated to be a successful ablation technique for pancreatic, renal, and liver tumors and is widely used as a focal therapeutic option for prostate cancer. The need for specific anesthetic management and accurate parallel placement of multiple electrodes entails a high level of complexity and great expertise from the interventional team is required. Nevertheless, IRE is a very promising technique with a remarkable systemic immunological capability and may impact on distant metastases (abscopal effect).
(Copyright © 2023 SERAM. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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