Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA.
| Autor: | Jarrous N; Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 9112010, Israel. Electronic address: jarrous@md.huji.ac.il., Mani D; Department of Microbiology and Molecular Genetics, IMRIC, The Hebrew University-Hadassah Medical School, Jerusalem 9112010, Israel. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Molecular cell [Mol Cell] 2024 Feb 15; Vol. 84 (4), pp. 619-620. |
| DOI: | 10.1016/j.molcel.2024.01.010 |
| Abstrakt: | Leone et al. 1 reveal that Pol III transcription complexes recruit a chaperone, HSP70, to execute cotranscriptional cleavage of precursor tRNA. HSP70 binds to the polymerase and translocates to nascent precursor tRNA and then tRNA. The last complex facilitates Pol III to engage in a new, efficient transcription cycle with another HSP70. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2024 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|