Analysis of sexual dysfunction development among male and female living kidney donors.

Autor:	Johnson JC; John Sealy School of Medicine, Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0655, United States., Venna R; John Sealy School of Medicine, Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0655, United States., Alzweri L; John Sealy School of Medicine, Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0655, United States.; Division of Urology, Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555-0655, United States.
Jazyk:	angličtina
Zdroj:	Sexual medicine reviews [Sex Med Rev] 2024 Mar 26; Vol. 12 (2), pp. 183-191.
DOI:	10.1093/sxmrev/qeae003
Abstrakt:	Introduction: Living kidney donations (LKDs) face a persistent demand for patients with end-stage renal disease, emphasizing the importance of LKDs' growth and success. Although living kidney donors generally exhibit excellent survival rates, little research has explored the development of long-term sexual dysfunction following LKD. Objectives: This study aimed to analyze differences in 5-year sexual dysfunction outcomes between male and female living kidney donors, utilizing the TriNetX database, a federated network of electronic medical records from multiple U.S. healthcare organizations. Methods: A propensity score-matched cohort study compared 45-year sexual dysfunction outcomes in adult male and female living kidney donors from December 2013 to December 2022. Cohorts were matched on age; sex; race and ethnicity; diabetes, cardiovascular, genitourinary, and psychiatric comorbidities; lifestyle-related factors; and medications that may impact normal sexual functioning. Primary outcomes included hazard ratio (HR) for decreased libido, sexual dysfunction (composite of male erectile dysfunction, ejaculatory disorders, vaginismus/dyspareunia, infertility, orgasmic disorders, arousal/desire disorders), and sexually transmitted diseases. Secondary outcomes assessed sex counseling and interpersonal relationship issues with spouses or partners. Results: The matched cohorts included 2315 patients each (male, female), and the mean age was 42.3 ± 12.5 years. At 5 years, male donors had a significantly higher HR for sexual dysfunction (HR, 3.768; 95% confidence interval, 1.929-7.358). Erectile dysfunction occurred in 1% of male patients, while vaginismus/dyspareunia affected <1% of female patients. Other sexual disorders, decreased libido, sexually transmitted diseases, and incidences of sexual and interspousal counseling were not significantly different. Conclusion: Male living kidney donors faced a higher risk of developing sexual dysfunction 5 years after donation. While LKD remains a safe and viable alternative, clinicians and donors should be mindful of the potential association with sexual dysfunction postdonation. Further research may enhance support for the well-being of living kidney donors. (© The Author(s) 2024. Published by Oxford University Press on behalf of The International Society of Sexual Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu