Prevalence and Predictive Factors for Celiac Disease in Children With Type 1 Diabetes: Whom and When to Screen? A Nationwide Longitudinal Cohort Study of Swedish Children.

Autor:	Lindgren M; Department of Clinical Science, Lund University, Lund, Sweden.; Department of Paediatrics, Vrinnevi Hospital, Norrköping, Sweden., Norström F; Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden., Persson M; Department of Medicine, Clinical Epidemiology, Karolinska University Hospital, Stockholm, Sweden., Elding Larsson H; Department of Clinical Science Malmö, Lund University, Lund, Sweden.; Department of Paediatrics, Skåne University Hospital, Malmö/Lund, Sweden., Forsander G; Department of Paediatrics, Institute for Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden., Åkesson K; Division of Paediatrics, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.; Department of Paediatrics, County Hospital Ryhov, Jönköping, Sweden., Samuelsson U; Division of Paediatrics, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.; Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden., Ludvigsson J; Division of Paediatrics, Department of Biomedical and Clinical Science, Linköping University, Linköping, Sweden.; Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden., Carlsson A; Department of Clinical Science, Lund University, Lund, Sweden.; Department of Paediatrics, Skåne University Hospital, Malmö/Lund, Sweden.
Jazyk:	angličtina
Zdroj:	Diabetes care [Diabetes Care] 2024 Apr 01; Vol. 47 (4), pp. 756-760.
DOI:	10.2337/dc23-1671
Abstrakt:	Objective: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines. Research Design and Methods: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes Diagnosis study in Sweden. Results: The prevalence of biopsy-proven CD was 9.8%, of which 58.2% already had a CD diagnosis before or at T1D onset. Almost all, 95.9%, were diagnosed with CD within 5 years after the T1D diagnosis. Younger age at the T1D diagnosis and being homozygote for DQ2 increased the risk of CD after T1D, but neither sex nor diabetes-related autoantibodies were associated with the risk. Conclusions: Age at and time after diabetes diagnosis should be considered in screening guidelines for CD in children with T1D. (© 2024 by the American Diabetes Association.)
Databáze:	MEDLINE
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