Is rest-activity rhythm prospectively associated with all-cause mortality in older people regardless of sleep and physical activity level? The 'Como Vai?' Cohort study.

Autor: Wendt A; Graduate Program in Health Technology, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil., Bielemann RM; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; School of Nutrition, Federal University of Pelotas, Pelotas, Brazil., Wehrmeister FC; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Ricardo LIC; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Müller WA; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Machado AKF; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., da Cruz MF; Federal University of Pelotas, Pelotas, Brazil., Bertoldi AD; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Brage S; Medical Research Council Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom., Ekelund U; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.; Department of Chronic diseases, Norwegian Institute of Public Health, Oslo, Norway., Tovo-Rodrigues L; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil., Crochemore-Silva I; Post-Graduation Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; Post-Graduation Program in Physical Education, Federal University of Pelotas, Pelotas, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 16; Vol. 19 (2), pp. e0298031. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0298031
Abstrakt: Objective: This study aims to test the association of rest-activity rhythm (intradaily variability and interdaily stability) with all-cause mortality in an older adult cohort in Brazil. It also assesses whether the amount of time spent at each intensity level (i.e., physical activity and nocturnal sleep) interferes with this association.
Methods: This cohort study started in 2014 with older adults (≥60 years). We investigated deaths from all causes that occurred until April 2017. Rest-activity rhythm variables were obtained using accelerometry at baseline. Intradaily variability indicates higher rhythm fragmentation, while interdaily stability indicates higher rhythm stability. Cox proportional-hazard models were used to test the associations controlling for confounders.
Results: Among the 1451 older adults interviewed in 2014, 965 presented valid accelerometry data. During the follow-up period, 80 individuals died. After adjusting the analysis for sociodemographic, smoking, morbidity score, and number of medicines, an increase of one standard deviation in interdaily stability decreased 26% the risk of death. The adjustment for total sleep time and inactivity did not change this association. On the other hand, the association was no longer significant after adjusting for overall physical activity and moderate to vigorous physical activity.
Conclusion: Rest-activity rhythm pattern was not associated with mortality when physical activity was considered, possibly because this pattern could be driven by regular exercise. Promoting physical activity remains a relevant strategy to improve population health.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Wendt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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