Role of ketogenic diet in neurodegenerative diseases focusing on Alzheimer diseases: The guardian angle.

Autor: Al-Kuraishy HM; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq. Electronic address: haydermutter@uomustansiriyah.edu.iq., Jabir MS; Department of Applied Science, University of Technology Iraq. Electronic address: 100131@uotechnology.edu.iq., Albuhadily AK; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq. Electronic address: alikadhim@uomustansiriyah.edu.iq., Al-Gareeb AI; Department of Clinical Pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq; Jabir Ibn Hayyan Medical University, Al-Ameer Qu./Najaf-iraq, PO.Box13, Kufa, Iraq. Electronic address: dr.alialgareeb78@yahoo.com., Jawad SF; Department of Pharmacy, Al-Mustaqbal University College, Hillah, Babylon, 51001, Iraq. Electronic address: sabrean.f.Jawaad@uomus.edu.iq., Swelum AA; Department of Animal Production, King Saud University, Riyadh, Saudi Arabia. Electronic address: aswelum@ksu.edu.sa., Hadi NR; Faculty of Medicine University of Kufa, Iraq.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Mar; Vol. 95, pp. 102233. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1016/j.arr.2024.102233
Abstrakt: The ketogenic diet (KD) is a low-carbohydrate, adequate protein and high-fat diet. KD is primarily used to treat refractory epilepsy. KD was shown to be effective in treating different neurodegenerative diseases. Alzheimer disease (AD) is the first common neurodegenerative disease in the world characterized by memory and cognitive impairment. However, the underlying mechanism of KD in controlling of AD and other neurodegenerative diseases are not discussed widely. Therefore, this review aims to revise the fundamental mechanism of KD in different neurodegenerative diseases focusing on the AD. KD induces a fasting-like which modulates the central and peripheral metabolism by regulating mitochondrial dysfunction, oxidative stress, inflammation, gut-flora, and autophagy in different neurodegenerative diseases. Different studies highlighted that KD improves AD neuropathology by regulating synaptic neurotransmission and inhibiting of neuroinflammation and oxidative stress. In conclusion, KD improves cognitive function and attenuates the progression of AD neuropathology by reducing oxidative stress, mitochondrial dysfunction, and enhancing neuronal autophagy and brain BDNF.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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