Pulmonary Cellular Toxicity in Alpha-1 Antitrypsin Deficiency.

Autor: Abo KM; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA., Merritt C; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA., Basil MC; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Lin SM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Cantu E; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Morley MP; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Bawa P; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA., Gallagher M; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA., Byers DE; Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO., Morrisey EE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Wilson AA; Center for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA. Electronic address: awilson@bu.edu.
Jazyk: angličtina
Zdroj: Chest [Chest] 2024 Sep; Vol. 166 (3), pp. 472-479. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1016/j.chest.2024.02.013
Abstrakt: Competing Interests: Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: E. C. reports research funding from XVIVO Inc, CareDx, and Pulmocide as well as consulting fees from CSL Behring and United Therapeutics and serves in a leadership position for ISHLT and UNOS and as a consultant for the US Food and Drug Administration. A. A. W. has received research funding from Grifols, Inc. and Beam Therapeutics within the last 3 years for projects distinct from this work and serves as the Scientific Director of the Alpha-1 Foundation. None declared (K. M. A., C. M., M. C. B., S. M. L., M. P. M., P. B., M. G., D. E. B., E. E. M).
Databáze: MEDLINE