Integrating antimicrobial photodynamic therapy into the adjuvant phototherapeutic approach for orofacial manifestations of toxic epidermal necrolysis and Stevens-Johnson syndrome.

Autor: Raffaele RM; Dentistry Service, Charity Hospital of Campo Grande. Campo Grande, MS, Brazil., Ramires MCCH; Doutor José de Carvalho Florence Hospital, São José dos Campos, SP, Brazil., Baldo ME; Graduate Program on Health and Development in West Central Region, Federal University of Mato Grosso do Sul. Campo Grande, MS, Brazil., Palma LF; Department of Pathology, Federal University of São Paulo. São Paulo, SP, Brazil., Campos L; Graduate Program in Implantology, University of Santo Amaro, School of Dentistry. São Paulo, SP, Brazil. Electronic address: lucampos@prof.unisa.br.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Apr; Vol. 46, pp. 104011. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1016/j.pdpdt.2024.104011
Abstrakt: Characterized by an immune reaction to medications, toxic epidermal necrolysis (TEN) and Steven-Johnson Syndrome (SJS) are potentially fatal mucocutaneous reactions, and their management remains challenging. Considering the promising studies regarding the use of laser in managing orofacial lesions, this study aimed to report two cases in which children presenting with TEN and SJS were treated using a combination of antimicrobial photodynamic therapy (aPDT) and photobiomodulation therapy (PBMT) concurrently with conventional supportive care. The treatment proposed herein resulted in significant clinical improvement of the children's oral condition within a few days, enabling the reintroduction of oral feeding. Within the limitations of the study, the cases reported suggest that the adjuvant combination of PBMT and aPDT may be beneficial for improving the oral condition of children afflicted with oral injuries induced by TEN and SJS.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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