Are fetal microchimerism and circulating fetal extracellular vesicles important links between spontaneous preterm delivery and maternal cardiovascular disease risk?
Autor: | Bonney EA; Department of Obstetrics, Gynecology, and Reproductive Sciences, Larner College of Medicine, The University of Vermont, Burlington, Vermont, USA., Lintao RCV; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA.; College of Medicine, University of the Philippines Manila, Manila, Philippines., Zelop CM; The Valley Hospital, Ridgewood, Paramus, New Jersey, USA.; Grossman School of Medicine, New York University, New York City, New York, USA., Kammala AK; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA., Menon R; Division of Basic Science and Translational Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas, USA. |
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Jazyk: | angličtina |
Zdroj: | BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 Apr; Vol. 46 (4), pp. e2300170. Date of Electronic Publication: 2024 Feb 15. |
DOI: | 10.1002/bies.202300170 |
Abstrakt: | Trafficking and persistence of fetal microchimeric cells (fMCs) and circulating extracellular vesicles (EVs) have been observed in animals and humans, but their consequences in the maternal body and their mechanistic contributions to maternal physiology and pathophysiology are not yet fully defined. Fetal cells and EVs may help remodel maternal organs after pregnancy-associated changes, but the cell types and EV cargos reaching the mother in preterm pregnancies after exposure to various risk factors can be distinct from term pregnancies. As preterm delivery-associated maternal complications are rising, revisiting this topic and formulating scientific questions for future research to reduce the risk of maternal morbidities are timely. Epidemiological studies report maternal cardiovascular risk as one of the major complications after preterm delivery. This paper suggests a potential link between fMCs and circulating EVs and adverse maternal cardiovascular outcomes post-pregnancies, the underlying mechanisms, consequences, and methods for and how this link might be assessed. (© 2024 Wiley Periodicals LLC.) |
Databáze: | MEDLINE |
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