Therapeutic applications of melatonin in disorders related to the gastrointestinal tract and control of appetite.

Autor: Moghadam Fard A; Universal Scientific Educational and Research Network (USERN), Tehran, Iran., Goodarzi P; School of Medicine, Iran University of Medical Sciences, Tehran, Iran., Mottahedi M; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Garousi S; Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Zadabhari H; Physiotherapy and Rehabilitation Faculty, Medipol University Health of Science, Istanbul, Turkey., Kalantari Shahijan M; Faculty of Paramedicine, Lorestan University of Medical Sciences, Khorram Abad, Iran., Esmaeili S; Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran., Nabi-Afjadi M; Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. mohsennabi66@gmail.com., Yousefi B; Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. yousefib@tbzmed.ac.ir.; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. yousefib@tbzmed.ac.ir.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 Feb 15. Date of Electronic Publication: 2024 Feb 15.
DOI: 10.1007/s00210-024-02972-5
Abstrakt: Most animals have large amounts of the special substance melatonin, which is controlled by the light/dark cycle in the suprachiasmatic nucleus. According to what is now understood, the gastrointestinal tract (GIT) and other areas of the body are sites of melatonin production. According to recent studies, the GIT and adjacent organs depend critically on a massive amount of melatonin. Not unexpectedly, melatonin's many biological properties, such as its antioxidant, anti-inflammatory, pro-apoptotic, anti-proliferative, anti-metastasis, and antiangiogenic properties, have drawn the attention of researchers more and more. Because melatonin is an antioxidant, it produces a lot of secretions in the GIT's mucus and saliva, which shields cells from damage and promotes the development of certain GIT-related disorders. Melatonin's ability to alter cellular behavior in the GIT and other associated organs, such as the liver and pancreas, is another way that it functions. This behavior alters the secretory and metabolic activities of these cells. In this review, we attempted to shed fresh light on the many roles that melatonin plays in the various regions of the gastrointestinal tract by focusing on its activities for the first time.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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