SD-Bioline malaria rapid diagnostic test performance and time to become negative after treatment of malaria infection in Southwest Nigerian Children.

Autor: Orimadegun AE; Institute of Child Health, College of Medicine, University of Ibadan, Ibadan, Nigeria., Dada-Adegbola HO; Departments of Medical Microbiology, College of Medicine, University of Ibadan, Ibadan, Nigeria., Michael OS; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Adepoju AA; Department of Paediatrics College of Medicine, University of Ibadan, Ibadan, Nigeria., Funwei RI; Department of Pharmacology, Babcock University, Ogun State, Nigeria., Olusola FI; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ajayi IO; epartment of Epidemiology and Biostatistics, College of Medicine, University of Ibadan, Ibadan, Nigeria., Ogunkunle OO; Department of Paediatrics College of Medicine, University of Ibadan, Ibadan, Nigeria., Ademowo OG; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan; Institute for Advanced Medical Research and Training, College of Medicine, Ibadan, Nigeria., Jegede AS; Department of Sociology, Faculty of the Social Sciences, University of Ibadan, Ibadan, Nigeria., Baba E; Malaria Consortium Regional Office for Africa, Kampala, Uganda., Hamade P; Malaria Consortium, London, United Kingdom., Webster J; London School of Tropical Medicine and Hygiene, London, United Kingdom., Chandramohan D; London School of Tropical Medicine and Hygiene, London, United Kingdom., Falade CO; Department of Pharmacology and Therapeutics, College of Medicine, University of Ibadan; Institute for Advanced Medical Research and Training, College of Medicine, Ibadan, Nigeria.
Jazyk: angličtina
Zdroj: Annals of African medicine [Ann Afr Med] 2023 Oct-Dec; Vol. 22 (4), pp. 470-480.
DOI: 10.4103/aam.aam_220_21
Abstrakt: Context and Aim: Given the challenges of microscopy, we compared its performance with SD-Bioline malaria rapid diagnostic test (MRDT) and polymerase chain reaction (PCR) and evaluated the time it took for positive results to become negative after treatment of children with acute uncomplicated malaria.
Subjects and Methods: We present the report of 485 participants with complete MRDT, microscopy, and PCR data out of 511 febrile children aged 3-59 months who participated in a cohort study over a 12-month period in rural and urban areas of Ibadan, Nigeria. MRDT-positive children received antimalaria and tested at every visit over 28 days. Speciation was also carried out by PCR.
Results: With microscopy as the gold standard, SD-Bioline™ had 95.2% sensitivity, 66.4% specificity, 67.5% positive predictive value (PPV), and 94.9 negative predictive value (NPV), while with PCR the findings were 84.3% sensitivity, 66.5% specificity, 72.7% PPV, and 80.1% NPV. PCR speciation of malaria parasites revealed 91.6% Plasmodium falciparum, 18.9% Plasmodium malariae, and 4.4% Plasmodium ovale. Among the 47 children with P. malariae infections, 66.0% were coinfected with P. falciparum, while 54.6% cases of P. ovale occurred as coinfections with P. falciparum. The median time to a negative MRDT was 23.2 days, while the median time to a negative malaria microscopy was 3.8 days. The two survival curves were significantly different.
Conclusions: The SD-Bioline TM MRDT performed well, with remarkable persistence of rapid test-positive for an average of 23 days post treatment. The prevalence of P. malaria is somewhat greater than expected.
Competing Interests: None
Databáze: MEDLINE
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