Nanomaterials in electrochemical nanobiosensors of miRNAs.

Autor: Mousazadeh M; Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Daneshpour M; Biotechnology Department, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Livogen Pharmed, Research and Innovation Center, Tehran, Iran., Rafizadeh Tafti S; Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, 89195-999, Yazd, Iran. m.azimzadeh@ssu.ac.ir., Shoaie N; Department of Biotechnology, Tarbiat Modares University of Medical Science, Tehran, Iran., Jahanpeyma F; Department of Biotechnology, Tarbiat Modares University of Medical Science, Tehran, Iran., Mousazadeh F; Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran., Khosravi F; Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, 89195-999, Yazd, Iran. m.azimzadeh@ssu.ac.ir., Khashayar P; Center for Microsystems Technology, Imec and Ghent University, 9050, Ghent, Belgium. patricia.khashayar@ugent.be., Azimzadeh M; Medical Nanotechnology & Tissue Engineering Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, 89195-999, Yazd, Iran. m.azimzadeh@ssu.ac.ir.; Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, 89195-999, Yazd, Iran.; Department of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd 89165-887, Iran., Mostafavi E; Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. ebimsv@stanford.edu.
Jazyk: angličtina
Zdroj: Nanoscale [Nanoscale] 2024 Mar 07; Vol. 16 (10), pp. 4974-5013. Date of Electronic Publication: 2024 Mar 07.
DOI: 10.1039/d3nr03940d
Abstrakt: Nanomaterial-based biosensors have received significant attention owing to their unique properties, especially enhanced sensitivity. Recent advancements in biomedical diagnosis have highlighted the role of microRNAs (miRNAs) as sensitive prognostic and diagnostic biomarkers for various diseases. Current diagnostics methods, however, need further improvements with regards to their sensitivity, mainly due to the low concentration levels of miRNAs in the body. The low limit of detection of nanomaterial-based biosensors has turned them into powerful tools for detecting and quantifying these biomarkers. Herein, we assemble an overview of recent developments in the application of different nanomaterials and nanostructures as miRNA electrochemical biosensing platforms, along with their pros and cons. The techniques are categorized based on the nanomaterial used.
Databáze: MEDLINE