Natural flavonoids as potential therapeutics in the management of Alzheimer's disease: a review.

Autor: Nguyen-Thi PT; Faculty of Pharmacy, HUTECH University, Ho Chi Minh City, 700000 Vietnam., Vo TK; Department of Sports Medicine, Faculty of Medicine, VNU University of Medicine and Pharmacy, Vietnam National University, Hanoi, 100000 Vietnam., Pham THT; Institute for Global Health Innovations, Duy Tan University, Da Nang, 550000 Vietnam.; Faculty of Pharmacy, Duy Tan University, Da Nang, 550000 Vietnam., Nguyen TT; Faculty of Chemical Engineering, Industrial University of Ho Chi Minh City, Ho Chi Minh City, 71420 Vietnam., Van Vo G; Department of Biomedical Engineering, School of Medicine, Vietnam National University - Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000 Vietnam.; Research Center for Genetics and Reproductive Health (CGRH), School of Medicine, Vietnam National University, Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 70000 Vietnam.; Vietnam National University - Ho Chi Minh City (VNU-HCM), Ho Chi Minh City, 700000 Vietnam.
Jazyk: angličtina
Zdroj: 3 Biotech [3 Biotech] 2024 Mar; Vol. 14 (3), pp. 68. Date of Electronic Publication: 2024 Feb 13.
DOI: 10.1007/s13205-024-03925-8
Abstrakt: Alzheimer's disease (AD) is an age-dependent neurodegenerative disorder which is associated with the accumulation of proteotoxic Aβ peptides, and pathologically characterized by the deposition of Aβ-enriched plaques and neurofibrillary tangles. Given the social and economic burden caused by the rising frequency of AD, there is an urgent need for the development of appropriate therapeutics. Natural compounds are gaining popularity as alternatives to synthetic drugs due to their neuroprotective properties and higher biocompatibility. While natural compound's therapeutic effects for AD have been recently investigated in numerous in vitro and in vivo studies, only few have developed to clinical trials. The present review aims to provide a brief overview of the therapeutic effects, new insights, and upcoming perspectives of the preclinical and clinical trials of flavonoids for the treatment of Alzheimer's disease.
Competing Interests: Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.
(© King Abdulaziz City for Science and Technology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
Databáze: MEDLINE
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