Longitudinal changes in peri-papillary retinal nerve fiber layer thickness in patients with unilateral branch retinal vein occlusion.

Autor:	Goda I; Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt., Saliem EA; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Mostafa SM; Department of Ophthalmology, Faculty of Medicine for Girls, Al-Azhar University, Assiut, Egypt., Amin AM; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Omran MY; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt., Eltantawy B; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt., Soliman HB; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt., Abu El-Wafa EG; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Abdelgbar AA; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Abdel-Rahman Osman HO; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Assiut, Egypt., Madianah Alkady AM; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Alneklawi MFM; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Abdel Hamid NE; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Elgazzar AF; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt., Abdella WS; Department of Ophthalmology, Faculty of Medicine, Al-Azhar University, Damietta, Egypt., Saleh MGA; Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Jazyk:	angličtina
Zdroj:	Medical hypothesis, discovery & innovation ophthalmology journal [Med Hypothesis Discov Innov Ophthalmol] 2023 Dec 31; Vol. 12 (2), pp. 62-69. Date of Electronic Publication: 2023 Dec 31 (Print Publication: 2023).
DOI:	10.51329/mehdiophthal1471
Abstrakt:	Background: Associations between retinal venous occlusion (RVO), elevated intraocular pressure, and glaucoma have been reported. Further investigations into structural alterations in the fellow eyes of individuals with unilateral RVO have revealed that the peripapillary retinal nerve fiber layer is thinner than in healthy eyes, suggesting that there may be systemic risk factors common to both RVO and glaucoma. We aimed to evaluate changes in peripapillary retinal nerve fiber layer thickness (pRNFLT) among individuals with unilateral branch retinal vein occlusion (BRVO). Methods: This prospective observational study recruited 30 individuals (60 eyes) with newly diagnosed unilateral BRVO and macular edema, and a control group of 30 healthy individuals (30 eyes) with no abnormalities on fundus examination or concurrent systemic comorbidities. After baseline measurements, the participants were reassessed at 6, 12, and 24 months by measuring global and sectoral pRNFLT using spectral-domain optical coherence tomography. Results: The mean age and sex distributions were comparable between the patient and control groups (both P  > 0.05). When compared to fellow eyes, global and sectoral pRNFLT in eyes with BRVO were significantly higher at baseline (all P  < 0.05). Over time, pRNFLT decreased dramatically, and by the conclusion of the two-year follow-up, there was a significant reduction from baseline in the affected eyes (all P  < 0.05). Likewise, affected eyes experienced a significant improvement in best-corrected distance visual acuity and central macular thickness over the two-year follow-up (both P  ≤ 0.001). Comparing the global and all-sector pRNFLT of fellow eyes in the patient group with those of normal eyes in the control group, there were no significant differences at any visit, except in the temporal sector, which revealed a significant reduction in pRNFLT at 24 months in the fellow eyes of patients with unilateral BRVO ( P  = 0.02). Conclusions: Patients with unilateral BRVO experienced a significant reduction in pRNFLT in the affected eyes and, to a lesser extent, in the fellow eyes, compared with that of the control arm, suggesting that they are prone to retinal nerve fiber layer damage. The reduction in pRNFLT in the normal fellow eyes of patients with BRVO may be attributed to age or concurrent systemic comorbidities. Further studies with long follow-up periods are required to shed light on the etiology of functional and structural changes in both the retinal nerve fiber layer and ganglion cell complex in the normal and affected eyes of patients with unilateral BRVO. Competing Interests: None. (© Author(s).)
Databáze:	MEDLINE
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