Screen-Printed Sensors Modified with Nafion and Mesoporous Carbon for Electrochemical Detection of Lead in Blood.
| Autor: | Boselli E; Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois 60607, United States of America., Wu Z; Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois 60607, United States of America., Haynes EN; Departments of Epidemiology and Preventive Medicine and Environmental Health, University of Kentucky, Kentucky 40536, United States of America., Papautsky I; Department of Biomedical Engineering, University of Illinois Chicago, Chicago, Illinois 60607, United States of America. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the Electrochemical Society [J Electrochem Soc] 2024 Feb 01; Vol. 171 (2), pp. 027513. Date of Electronic Publication: 2024 Feb 13. |
| DOI: | 10.1149/1945-7111/ad2397 |
| Abstrakt: | Lead (Pb) has long been acknowledged as a systemic toxicant, with pronounced health impacts observed even at low exposure levels, particularly in children. Adverse effects include diminished cognitive function, altered behavior, and developmental delays. Consequently, it is imperative to conduct regular monitoring of Blood Lead Levels (BLLs). In this work, we report on an electrochemical sensor based on screen-printed carbon electrode (SPCE) coated with Nafion and mesoporous carbon (MC). The sensor system uses simple sample preparation (acidification and dilution of whole blood), minimal sample volume (a few blood drops, 200 μ l), and swift time-to-results (1 h). A limit of quantitation (LOQ) of 0.3 μ g dL -1 Pb was achieved in whole blood. To demonstrate the practical utility of our sensor system, we evaluated its performance in the analysis of blood samples collected from children (n = 25). Comparative analysis with the laboratory-based gold standard method of inductively coupled plasma mass spectrometry (ICP-MS) demonstrated approximately 77% accuracy and 94% precision. We anticipate that our approach will serve as a valuable tool for more frequent BLL monitoring, particularly in communities where access to laboratory testing is impractical or expensive. (© 2024 The Author(s). Published on behalf of The Electrochemical Society by IOP Publishing Limited.) |
| Databáze: | MEDLINE |
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