Association between F2-isoprostanes and self-reported stressors in pregnant americans of African and European ancestry.

Autor:	Rose DK; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Bentley L; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA., Maity A; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.; Department of Statistics, North Carolina State University, Raleigh, NC, USA., Maguire RL; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA., Planchart A; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA., Spasojevic I; Department of Medicine, Duke University School of Medicine, Durham, NC, USA.; Duke Cancer Institute, PK/PD Core Laboratory, Durham, NC, USA., Liu AJ; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Thorp J Jr; Gillings School of Public Health, University of North Carolina, Chapel Hill, NC, USA., Hoyo C; Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA.; Center for Human Health and the Environment, North Carolina State University, Raleigh, NC, USA.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 Feb 06; Vol. 10 (3), pp. e25578. Date of Electronic Publication: 2024 Feb 06 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e25578
Abstrakt:	Background: Poor birth outcomes such as preterm birth/delivery disproportionately affect African Americans compared to White individuals. Reasons for this disparity are likely multifactorial, and include prenatal psychosocial stressors, and attendant increased lipid peroxidation; however, empirical data linking psychosocial stressors during pregnancy to oxidative status are limited. Methods: We used established scales to measure five psychosocial stressors. Maternal adverse childhood experiences, financial stress, social support, anxiety, and depression were measured among 50 African American and White pregnant women enrolled in the Stress and Health in Pregnancy cohort. Liquid chromatography-tandem mass spectrometry was used to measure biomarkers of oxidative stress (four urinary F2-isoprostane isomers), to estimate oxidative status. Linear regression models were used to evaluate associations between psychosocial stressors, prenatal oxidative status and preterm birth. Results: After adjusting for maternal obesity, gestational diabetes, and cigarette smoking, African American women with higher oxidative status were more likely to report higher maternal adverse childhood experience scores (β = 0.16, se = 1.07, p-value = 0.024) and depression scores (β = 0.05, se = 0.02, p = 0.014). Higher oxidative status was also associated with lower gestational age at birth (β = -0.13, se = 0.06, p = 0.04) in this population. These associations were not apparent in Whites. However, none of the cross-product terms for race/ethnicity and social stressors reached statistical significance (p > 0.05). Conclusion: While the small sample size limits inference, our novel data suggest that psychosocial stressors may contribute significantly to oxidative stress during pregnancy, and preterm birth or delivery African Americans. If replicated in larger studies, these findings would support oxidative stress reduction using established dietary or pharmacological approaches present a potential avenue to mitigate adverse effects of psychosocial stressors on birth outcomes. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu