Evaluation of racial and ethnic heterogeneity in the associations of sleep quality and sleep apnea risk with cognitive function and cognitive decline.
| Autor: | Chen R; Department of Epidemiology School of Public Health Boston University Boston Massachusetts USA., Wang J; Department of Epidemiology and Biostaistics University of California, San Francisco San Francisco California USA., Pederson AM; Department of Epidemiology School of Public Health Boston University Boston Massachusetts USA., Prather AA; Department of Psychiatry and Behavioral Sciences University of California San Francisco California USA., Hirst AK; Division of Research Kaiser Permanente Northern California Oakland California USA., Ackley S; Department of Epidemiology School of Public Health Boston University Boston Massachusetts USA., Hokett E; Department of Neurology Columbia University New York New York USA., George KM; Department of Public Health Sciences University of California Davis California USA., Mungas D; Department of Neurology University of California Davis California USA., Mayeda ER; Department of Epidemiology Fielding School of Public Health University of California Los Angeles California USA., Gilsanz P; Division of Research Kaiser Permanente Northern California Oakland California USA., Haneuse S; Department of Biostatistics Harvard T.H. Chan School of Public Health Boston Massachusetts USA., Whitmer RA; Department of Public Health Sciences University of California Davis California USA., Glymour MM; Department of Epidemiology School of Public Health Boston University Boston Massachusetts USA. |
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| Jazyk: | angličtina |
| Zdroj: | Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2024 Feb 11; Vol. 10 (1), pp. e12441. Date of Electronic Publication: 2024 Feb 11 (Print Publication: 2024). |
| DOI: | 10.1002/trc2.12441 |
| Abstrakt: | Introduction: The prevalence of poor sleep quality and sleep apnea differs by race and ethnicity and may contribute to racial disparities in cognitive aging. We investigated whether sleep quality and sleep apnea risk were associated with cognitive function and decline and whether the associations differed by race/ethnicity. Methods: Participants from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE; N = 1690; mean age: 75.7 years) study, a cohort of Asian, Black, Latino, and White participants, completed a modified Pittsburgh Sleep Quality Index assessing subjective sleep quality, latency, duration, disturbances, sleep medication use, and daytime dysfunction. Sleep apnea risk was measured by questions about snoring, tiredness, and whether apnea was observed. Executive function and verbal episodic memory were assessed at three time points over an average of 2.7 years with the Spanish and English Neuropsychological Assessment Scale. We fit linear mixed-effect models and stratified analyses by race/ethnicity. Results: Higher sleep apnea risk was associated with faster declines in verbal episodic memory ( β ^ Discussion: Observational evidence indicates sleep quality is a promising target for addressing racial/ethnic disparities in cognitive aging, especially among Black older adults. Highlights: Sleep apnea risk was associated with faster declines in verbal episodic memory but not executive function among all participants.Global sleep quality was associated with lower levels of and faster decline in executive function but not verbal episodic memory among all participants.Black older adults were particularly susceptible to the estimated adverse cognitive impacts of global sleep quality, particularly the use of sleep medication. Competing Interests: The authors declare no conflicts of interest. Author disclosures are available in the supporting information. (© 2024 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals LLC on behalf of Alzheimer's Association.) |
| Databáze: | MEDLINE |
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