Pleiotropy and genetically inferred causality linking multisite chronic pain to substance use disorders.
Autor: | Koller D; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. dora.koller@yale.edu.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA. dora.koller@yale.edu.; Department of Genetics, Microbiology, and Statistics, Faculty of Biology, University of Barcelona, Catalonia, Spain. dora.koller@yale.edu., Friligkou E; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Stiltner B; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Pathak GA; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Løkhammer S; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.; Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway., Levey DF; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Zhou H; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Hatoum AS; Department of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA., Deak JD; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA., Kember RL; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA., Treur JL; Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kranzler HR; Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Mental Illness Research, Education and Clinical Center, Veterans Integrated Service Network 4, Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA., Johnson EC; Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA., Stein MB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.; VA San Diego Healthcare System, San Diego, CA, USA.; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Gelernter J; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA.; Department of Genetics, Yale School of Medicine, New Haven, CT, USA.; Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.; Wu Tsai Institute, Yale University, New Haven, CT, USA., Polimanti R; Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA. renato.polimanti@yale.edu.; Veterans Affairs Connecticut Healthcare Center, West Haven, CT, USA. renato.polimanti@yale.edu.; Wu Tsai Institute, Yale University, New Haven, CT, USA. renato.polimanti@yale.edu. |
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Jazyk: | angličtina |
Zdroj: | Molecular psychiatry [Mol Psychiatry] 2024 Jul; Vol. 29 (7), pp. 2021-2030. Date of Electronic Publication: 2024 Feb 15. |
DOI: | 10.1038/s41380-024-02446-3 |
Abstrakt: | Individuals suffering from chronic pain develop substance use disorders (SUDs) more often than others. Understanding the shared genetic influences underlying the comorbidity between chronic pain and SUDs will lead to a greater understanding of their biology. Genome-wide association statistics were obtained from the UK Biobank for multisite chronic pain (MCP, N (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.) |
Databáze: | MEDLINE |
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