The role of thyroid function in borderline personality disorder and schizophrenia: a Mendelian Randomisation study.

Autor: Babajide O; Queen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK., Kjaergaard AD; Aarhus University Hospital, Steno Diabetes Center, Hedeager Aarhus, Denmark., Deng W; Queen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK., Kuś A; Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland., Sterenborg RBTM; Erasmus Medical Center, Academic Center for Thyroid Diseases, Department of Internal Medicine, Rotterdam, Netherlands.; Erasmus Medical Center, Department of Epidemiology, Rotterdam, Netherlands.; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Åsvold BO; Department of Public Health and Nursing, Department of Endocrinology, Clinic of Medicine, NTNU, Norwegian University of Science and Technology &, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway., Burgess S; University of Cambridge, MRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Teumer A; Institute of Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK German Center for Cardiovascular Research, Berlin, Germany., Medici M; Erasmus Medical Center, Academic Center for Thyroid Diseases, Department of Internal Medicine, Rotterdam, Netherlands., Ellervik C; Department of Laboratory Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Pathology, Harvard Medical School, Boston, MA, USA.; Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Nick B; Division of Psychiatry, University College London, Mental Health Neuroscience, London, UK., Deloukas P; Queen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK., Marouli E; Queen Mary University of London, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, London, UK. e.marouli@qmul.ac.uk.
Jazyk: angličtina
Zdroj: Borderline personality disorder and emotion dysregulation [Borderline Personal Disord Emot Dysregul] 2024 Feb 15; Vol. 11 (1), pp. 2. Date of Electronic Publication: 2024 Feb 15.
DOI: 10.1186/s40479-024-00246-3
Abstrakt: Background: Genome-wide association studies have reported a genetic overlap between borderline personality disorder (BPD) and schizophrenia (SCZ). Epidemiologically, the direction and causality of the association between thyroid function and risk of BPD and SCZ are unclear. We aim to test whether genetically predicted variations in TSH and FT4 levels or hypothyroidism are associated with the risk of BPD and SCZ.
Methods: We employed Mendelian Randomisation (MR) analyses using genetic instruments associated with TSH and FT4 levels as well as hypothyroidism to examine the effects of genetically predicted thyroid function on BPD and SCZ risk. Bidirectional MR analyses were employed to investigate a potential reverse causal association.
Results: Genetically predicted higher FT4 was not associated with the risk of BPD (OR: 1.18; P = 0.60, IVW) or the risk of SCZ (OR: 0.93; P = 0.19, IVW). Genetically predicted higher TSH was not associated with the risk of BPD (OR: 1.11; P = 0.51, IVW) or SCZ (OR: 0.98, P = 0.55, IVW). Genetically predicted hypothyroidism was not associated with BPD or SCZ. We found no evidence for a reverse causal effect between BPD or SCZ on thyroid function.
Conclusions: We report evidence for a null association between genetically predicted FT4, TSH or hypothyroidism with BPD or SCZ risk. There was no evidence for reverse causality.
(© 2024. The Author(s).)
Databáze: MEDLINE
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