The impact of time since SARS-Cov-2 vaccination, age, sex and comorbidities on COVID-19 outcome in hospitalized patients with SARS-CoV-2 infection.

Autor: Donato F; University Unit of Hygiene, Epidemiology and Public Health, University of Brescia, 25123 Brescia, Italy. Electronic address: francesco.donato@unibs.it., Pilotto A; Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Hospital, Brescia, Italy; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy., Focà E; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy., Tresoldi M; University Unit of Hygiene, Epidemiology and Public Health, University of Brescia, 25123 Brescia, Italy., Tonoli A; Emergency Department and Bed Management, ASST Spedali Civili Hospital, Brescia, Italy., Perani C; Emergency Department and Bed Management, ASST Spedali Civili Hospital, Brescia, Italy., Minisci D; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy., Salvetti M; Emergency Medicine Unit, Department of Clinical & Experimental Sciences, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy., Filippini M; Department of Anesthesia, Intensive Care and Emergency, ASST Spedali Civili Hospital, Brescia, Italy., Bezzi M; Division of Pneumology, ASST Spedali Civili Hospital, Brescia, Italy., Em Boari G; COVID_19 Medicine, Internal Medicine Unit, Montichiari Hospital, Montichiari, Italy., Gipponi S; Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Hospital, Brescia, Italy., Stegher C; Department of Obstetrics and Gynecology, ASST Spedali Civili Hospital, Brescia, Italy., Nardin M; Medicine III, ASST Spedali Civili Hospital, Brescia, Italy., Caruso A; Department of Molecular and Translational Medicine, Institute of Microbiology, ASST Spedali Civili Hospital, Brescia, Italy., Metra M; Cardiology Unit, Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Padovani A; Neurology Unit, Department of Continuity of Care and Frailty, ASST Spedali Civili Hospital, Brescia, Italy; Department of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy., Rossi C; Chief Medical Officer of ASST Spedali Civili Hospital Health Directorate, Brescia, Italy., Castelli F; University Division of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy.
Jazyk: angličtina
Zdroj: Vaccine [Vaccine] 2024 Mar 19; Vol. 42 (8), pp. 1863-1867. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1016/j.vaccine.2024.02.003
Abstrakt: We evaluated the impact of COVID-19 vaccination on disease outcome in hospitalized patients with SARS-CoV-2 infection with a prospective study. 745 vaccinated and 451 unvaccinated patients consecutively admitted to a COVID-19 Hospital from 1st September 2021 to 1st September 2022 were included. Compared with unvaccinated cases, vaccinated patients were older, had more comorbidities, but had a lower risk of O2 need (odds ratio, OR, 0.46; 95 % CI 0.32-0.65) by logistic regression analysis adjusted for age, sex, comorbidity and WHO COVID-19 Clinical Progression Scale at admission. The ORs for O2 need were 0.38 (0.24-0.61), 0.50 (0.30-0.83) and 0.57 (0.34-0.96) in patients vaccinated 14-120, 121-180 and > 180 days prior to hospitalization, respectively. An anti-spike Ig titer higher than 5000 U/ml was associated with a reduced risk of O2 need (OR 0.52; 95 % CI 0.30-0.92). This study shows that COVID-19 vaccination has a significant impact on COVID-19 outcomes in hospitalized patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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