Gallium maltolate, a promising low toxicity drug with curative effect on mice chronically infected with Trypanosoma evansi.

Autor: Rosa LD; Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul, Rua Ramiro, 2600 - Santa Cecília, Building 21116, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: luciana.rosa@ufrgs.br., Oliveira CB; Universidade Federal de Pelotas, Rio Grande do Sul, Brazil., Chaúque BJM; Department of Microbiology, Immunology and Parasitology, Universidade Federal do Rio Grande do Sul, Rua Ramiro, 2600 - Santa Cecília, Building 21116, Porto Alegre, Rio Grande do Sul, Brazil; Postgraduate Program in Biological Sciences, Pharmacology and Therapeutics, UFRGS, Rio Grande do Sul, Brazil; Center of Studies in Science and Technology (NECET), Biology Course, Universidade Rovuma, Niassa Branch, Lichinga, Mozambique., Grando TH; Instituto Federal Farroupilha, Rio Grande do Sul, Brazil., Gressler LT; Universidade de Cruz Alta, Rio Grande do Sul, Brazil., Bottari N; Universidade Federal de Pelotas, Rio Grande do Sul, Brazil., Monteiro SG; Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Acta tropica [Acta Trop] 2024 Apr; Vol. 252, pp. 107148. Date of Electronic Publication: 2024 Feb 12.
DOI: 10.1016/j.actatropica.2024.107148
Abstrakt: Trypanosoma evansi is a flagellate protozoan that infects a wide range of hosts, especially horses. Clinically, the infection is characterized by rapid weight loss, anemia and mobility disorders. This study evaluated the efficacy of treatment gallium maltolate (GaM) in rats infected with T. evansi in the acute and chronic phases of the disease and its influence on the enzyme and blood parameters. 48 animals (Rattus norvegicus) were divided into 8 groups (A-H) of 6 animals each, namely: A: (negative control) uninfected; B: acutely infected positive control; C: chronically infected positive control; D: acutely infected, treated with GaM for 7 days post infection (p.i.); E: acutely infected treated with GaM for 3 days before infection (b.i) and 7 days p.i.; F: chronically infected, treated with GaM for 7 days p.i.; G: chronically infected, treated with GaM for 3 days b.i. and 7 days p.i.; and H: uninfected treated with GaM for 10 days. Acute infected animals (B, D and E) had a progressive increase in parasitemia and were died or euthanized before completing treatment days (5th days p.i.) as they had high parasitemia (over 100 field trypanosomes in the blood smear). Thus, it can be concluded that GaM was not effective against an acute infection. In untreated chronically infected animals (C) the parasitemia also increased progressively and they were euthanized on the 7th day p.i.. The chronically infected and treated animals (F and G) showed low parasitemia and after treatment became negative, showing no trypanosomes in the bloodstream until the 50th day of the experiment. Thus, we conclude that GaM was effective against chronic infections. In uninfected and treated animals (H) hematological, biochemical and enzymatic parameters had no significant changes when compared to the negative control group (A) demonstrating the low toxicity of GaM.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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