Decreased sarcoplasmic reticulum phospholipids in human skeletal muscle are associated with metabolic syndrome.

Autor:	Adamson SE; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Adak S; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Petersen MC; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Higgins D; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Spears LD; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Zhang RM; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Cedeno A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., McKee A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Kumar A; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Singh S; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Hsu FF; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., McGill JB; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA., Semenkovich CF; Division of Endocrinology, Metabolism & Lipid Research, Washington University, St Louis, MO, USA; Department of Cell Biology & Physiology, Washington University, St Louis, MO, USA. Electronic address: csemenko@wustl.edu.
Jazyk:	angličtina
Zdroj:	Journal of lipid research [J Lipid Res] 2024 Mar; Vol. 65 (3), pp. 100519. Date of Electronic Publication: 2024 Feb 13.
DOI:	10.1016/j.jlr.2024.100519
Abstrakt:	Metabolic syndrome affects more than one in three adults and is associated with increased risk of diabetes, cardiovascular disease, and all-cause mortality. Muscle insulin resistance is a major contributor to the development of the metabolic syndrome. Studies in mice have linked skeletal muscle sarcoplasmic reticulum (SR) phospholipid composition to sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase activity and insulin sensitivity. To determine if the presence of metabolic syndrome alters specific phosphatidylcholine (PC) and phosphatidylethanolamine (PE) species in human SR, we compared SR phospholipid composition in skeletal muscle from sedentary subjects with metabolic syndrome and sedentary control subjects without metabolic syndrome. Both total PC and total PE were significantly decreased in skeletal muscle SR of sedentary metabolic syndrome patients compared with sedentary controls, particularly in female participants, but there was no difference in the PC:PE ratio between groups. Total SR PC levels, but not total SR PE levels or PC:PE ratio, were significantly negatively correlated with BMI, waist circumference, total fat, visceral adipose tissue, triglycerides, fasting insulin, and homeostatic model assessment for insulin resistance. These findings are consistent with the existence of a relationship between skeletal muscle SR PC content and insulin resistance in humans. Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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