Antiulcer activity of Mauritia flexuosa L.f. (Arecaceae) pulp oil: An edible Amazonian species with functional properties.

Autor: Rodrigues MF; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50740-525, Pernambuco, Brazil., da Silva JW; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50740-525, Pernambuco, Brazil., de Lima JS; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50740-525, Pernambuco, Brazil., Ramos BA; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50740-525, Pernambuco, Brazil., Paz ST; Departamento de Patologia, Universidade Federal de Pernambuco, Recife 50670-910, Pernambuco, Brazil., Lomonaco D; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza 60440-900, Ceará, Brazil., Zampieri D; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza 60440-900, Ceará, Brazil., Ximenes RM; Departamento de Antibióticos, Universidade Federal de Pernambuco, Recife 50740-525, Pernambuco, Brazil. Electronic address: rafael.ximenes@ufpe.br.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Apr; Vol. 174, pp. 105857. Date of Electronic Publication: 2024 Feb 12.
DOI: 10.1016/j.fitote.2024.105857
Abstrakt: Mauritia flexuosa, known as buriti in Brazil, is a widespread palm tree in Amazonia. It has many ethnobotanical uses, including food, oil, and medicine. The oil obtained from buriti's fruit pulp has high levels of monounsaturated fatty acids, carotenoids, and tocopherols, and is used in the food, cosmetic, and pharmaceutical industries for its antioxidant properties. Many biological activities have been reported for buriti oil, such as antioxidant, antimicrobial, chemopreventive, and immunomodulatory. Due to its high content of bioactive compounds, buriti oil is considered a functional ingredient with possible benefits in preventing oxidative stress and chronic diseases, particularly in the gastrointestinal tract. Peptic ulcer disease is a multifactorial disorder, involving lesions in the stomach and duodenum mucosa, which has a complex healing process. In this context, some nutrients and bioactive compounds help the maintenance of gastrointestinal mucosal integrity and function, such as carotenoids, tocopherols, and unsaturated fatty acids, which makes buriti oil an interesting candidate to be used in the prevention and management of gastrointestinal diseases. This study aimed to evaluate the gastroprotective and antiulcer effects of buriti oil and its possible mechanisms of action. Buriti oil reduced the ulcerative area and lipid peroxidation induced by ethanol. The gastroprotective activity of buriti oil partially depends on nitric oxide and sulfhydryl compounds. In acetic acid-induced gastric ulcers, buriti oil accelerated healing and stimulated the formation of new gastric glands. These results demonstrated the potential of buriti oil as a functional ingredient to promote health benefits in the gastrointestinal tract.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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