Comprehensive Ophthalmological Evaluation in Atopic Dermatitis.

Autor:	Valeille A; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Immunology and Allergy Clinic, University Claude Bernard Lyon 1, Lyon, France., Ouilhon C; Ophthalmology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France., Subtil F; Laboratoire de Biométrie et Biologie Évolutive, CNRS, University of Lyon, University Lyon 1, Villeurbanne, France.; Biostatistics Department, Hospices Civils de Lyon, Lyon, France., Hacard F; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Immunology and Allergy Clinic, University Claude Bernard Lyon 1, Lyon, France.; Ophthalmology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, CNRS, University of Lyon, University Lyon 1, Villeurbanne, France.; Biostatistics Department, Hospices Civils de Lyon, Lyon, France.; CIRI (International Center for Infectiology Research) INSERM U1111, Lyon Higher Normal School, University Claude Bernard Lyon 1, Lyon, France., Jaulent C; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France., Bérard F; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Immunology and Allergy Clinic, University Claude Bernard Lyon 1, Lyon, France.; Ophthalmology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, CNRS, University of Lyon, University Lyon 1, Villeurbanne, France.; Biostatistics Department, Hospices Civils de Lyon, Lyon, France.; CIRI (International Center for Infectiology Research) INSERM U1111, Lyon Higher Normal School, University Claude Bernard Lyon 1, Lyon, France., Nicolas JF; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Immunology and Allergy Clinic, University Claude Bernard Lyon 1, Lyon, France.; Ophthalmology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, CNRS, University of Lyon, University Lyon 1, Villeurbanne, France.; Biostatistics Department, Hospices Civils de Lyon, Lyon, France.; CIRI (International Center for Infectiology Research) INSERM U1111, Lyon Higher Normal School, University Claude Bernard Lyon 1, Lyon, France., Fauquert JL; Pediatric Allergy Unit, Clermont-Ferrand University Hospital, University Hospital Center Estaing, Clermont-Ferrand, France., Nosbaum A; Allergy and Clinical Immunology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Immunology and Allergy Clinic, University Claude Bernard Lyon 1, Lyon, France.; Ophthalmology Department, Lyon South University Hospital Center, Hospices Civils de Lyon, Lyon, France.; Laboratoire de Biométrie et Biologie Évolutive, CNRS, University of Lyon, University Lyon 1, Villeurbanne, France.; Biostatistics Department, Hospices Civils de Lyon, Lyon, France.; CIRI (International Center for Infectiology Research) INSERM U1111, Lyon Higher Normal School, University Claude Bernard Lyon 1, Lyon, France.
Jazyk:	angličtina
Zdroj:	Dermatology (Basel, Switzerland) [Dermatology] 2024; Vol. 240 (3), pp. 434-442. Date of Electronic Publication: 2024 Feb 14.
DOI:	10.1159/000536233
Abstrakt:	Introduction: Atopic dermatitis (AD), a chronic type 2 inflammatory skin disease, is frequently associated with ocular surface diseases (OSD) which may appear or worsen under anti-type 2-targeted treatments. However, the exact prevalence of OSD and the ophthalmology referral criteria remain ill-defined in AD patients before initiating such biotherapies. We aimed to characterize the prevalence, the nature and the factors related to OSD development in AD that may justify an ophthalmological management. Methods: A total of 98 consecutive AD inpatients without biological treatment were retrospectively included. These were systematically evaluated by an ophthalmologist during their dermatological care. Clinical and laboratory data were analysed to characterize OSD and their risk factors. Results: OSD were found in 83/98 AD patients (85%); mainly dry eye syndrome (64%, 63/98), allergic conjunctivitis (42%, 41/98), posterior (33%, 32/98), and anterior blepharitis (27%, 26/98). In AD patients without ocular symptoms, OSDs were also frequently found (63%, 12/19) and were mostly mild. Risk factors for OSD were history of allergic rhinitis, allergic sensitization, head and neck AD, ocular symptoms (foreign body sensation in the eye, burning, itching, photophobia), and total IgE level >3,000 kU/L. Conclusion: The prevalence of OSD was high, even in asymptomatic patients. The risk factors identified may indicate the need for ophthalmological examination for therapeutic management, especially when biological agents targeting type 2 inflammation are considered. (© 2024 S. Karger AG, Basel.)
Databáze:	MEDLINE
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