Multimorbidity and frailty are associated with poorer SARS-CoV-2-related outcomes: systematic review of population-based studies.

Autor: Makovski TT; Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France. tatjana.makovski@santepubliquefrance.fr., Ghattas J; Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.; Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium., Monnier-Besnard S; Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France., Cavillot L; Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium.; Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium., Ambrožová M; National screening centre, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic.; Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic., Vašinová B; National screening centre, Institute of Health Information and Statistics of the Czech Republic, Prague, Czech Republic., Feteira-Santos R; Área Disciplinar Autónoma de Bioestatística, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.; Laboratório Associado TERRA, Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Bezzegh P; Directorate for Project Management, National Directorate General for Hospitals, Budapest, Hungary., Bollmann FP; Universidad Nacional de Educación a Distancia, Madrid, Spain., Cottam J; Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.; Institute of Tropical Medicine, Antwerp, Belgium., Haneef R; Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France., Devleesschauwer B; Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium.; Department of Translational Physiology, Infectiology and Public Health, Ghent University, Merelbeke, Belgium., Speybroeck N; Institute of Health and Society (IRSS), Université catholique de Louvain, Brussels, Belgium., Nogueira PJ; Área Disciplinar Autónoma de Bioestatística, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.; Laboratório Associado TERRA, Instituto de Saúde Ambiental, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.; Centro de Investigação Em Saúde Pública, Escola Nacional de Saúde Pública, ENSP, CISP, Comprehensive Health Research Center, CHRC, Universidade NOVA de Lisboa, Lisbon, Portugal.; CIDNUR-Centro de Investigação, Inovação e Desenvolvimento Em Enfermagem de Lisboa Escola Superior de Enfermagem de Lisboa, Avenida Professor Egas Moniz, 1600-190, Lisbon, Portugal., Forjaz MJ; National Center of Epidemiology, Instituto de Salud Carlos III, RICAPPS, Madrid, Spain., Coste J; Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France., Carcaillon-Bentata L; Department of Non-Communicable Diseases and Injuries, French Public Health Agency (Santé publique France), Saint-Maurice, France.
Jazyk: angličtina
Zdroj: Aging clinical and experimental research [Aging Clin Exp Res] 2024 Feb 14; Vol. 36 (1), pp. 40. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1007/s40520-023-02685-4
Abstrakt: Background: Estimating the risks and impacts of COVID-19 for different health groups at the population level is essential for orienting public health measures. Adopting a population-based approach, we conducted a systematic review to explore: (1) the etiological role of multimorbidity and frailty in developing SARS-CoV-2 infection and COVID-19-related short-term outcomes; and (2) the prognostic role of multimorbidity and frailty in developing short- and long-term outcomes. This review presents the state of the evidence in the early years of the pandemic. It was conducted within the European Union Horizon 2020 program (No: 101018317); Prospero registration: CRD42021249444.
Methods: PubMed, Embase, World Health Organisation COVID-19 Global literature on coronavirus disease, and PsycINFO were searched between January 2020 and 7 April 2021 for multimorbidity and 1 February 2022 for frailty. Quantitative peer-reviewed studies published in English with population-representative samples and validated multimorbidity and frailty tools were considered.
Results: Overall, 9,701 records were screened by title/abstract and 267 with full text. Finally, 14 studies were retained for multimorbidity (etiological role, n = 2; prognostic, n = 13) and 5 for frailty (etiological role, n = 2; prognostic, n = 4). Only short-term outcomes, mainly mortality, were identified. An elevated likelihood of poorer outcomes was associated with an increasing number of diseases, a higher Charlson Comorbidity Index, different disease combinations, and an increasing frailty level.
Discussion: Future studies, which include the effects of recent virus variants, repeated exposure and vaccination, will be useful for comparing the possible evolution of the associations observed in the earlier waves.
(© 2024. The Author(s).)
Databáze: MEDLINE
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