Fetal chronic hypoxia does not affect urinary presepsin levels in newborns at birth.

Autor:	D'Adamo E; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Levantini G; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Librandi M; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Botondi V; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Di Ricco L; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., De Sanctis S; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Spagnuolo C; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy., Gazzolo F; Magna Graecia University, Catanzaro, Italy., Gavilanes DA; Department of Pediatrics and Neonatology, Maastricht University, Maastricht, The Netherlands., Di Gregorio P; Department of Services, SS Annunziata Hospital, Chieti, Italy., Di Monte J; Department of Services, SS Annunziata Hospital, Chieti, Italy., Strozzi MC; Department of Pediatrics and Neonatology, Ospedale Cardinal Massaia, Asti, Italy., Maconi A; Social Security Administration Development and Promotion of Scientific Research Unit, SS Antonio, Biagio and C. Arrigo Hospital, Alessandria, Italy., Cassinari M; Department of Clinical Biochemistry, Transfusion and Regeneration Medicine Alessandria Hospital, Alessandria, Italy., Libener R; Department of Clinical Biochemistry, Transfusion and Regeneration Medicine Alessandria Hospital, Alessandria, Italy., Gazzolo D; Neonatal Intensive Care Unit, G. d'Annunzio University, Chieti, Italy.
Jazyk:	angličtina
Zdroj:	Clinical chemistry and laboratory medicine [Clin Chem Lab Med] 2024 Feb 02; Vol. 62 (8), pp. 1643-1648. Date of Electronic Publication: 2024 Feb 02 (Print Publication: 2024).
DOI:	10.1515/cclm-2023-1308
Abstrakt:	Objectives: Early sepsis detection and diagnosis still constitutes an open issue since the accuracy of standard-of care parameters is biased by a series of perinatal factors including hypoxia. Therefore, we aimed at investigating the effect of fetal chronic hypoxia insult on urine levels of a promising new marker of sepsis, namely presepsin (P-SEP). Methods: We conducted a prospective case-control study in 22 cases of early-intrauterine growth restriction (E-IUGR) compared with 22 small-for-gestational-age (SGA) newborns and 66 healthy controls. P-SEP urine samples were collected over the first 72 h from birth. Blood culture and C-reactive protein (CRP) blood levels were measured in E-IUGR and SGA infants. Perinatal standard monitoring parameters and main outcomes were also recorded. Results: No significant urinary P-SEP differences (p>0.05, for all) were observed among studied groups. Moreover, no significant correlations (p>0.05, for both) between urinary P-SEP and blood CRP levels in both E-IUGR and SGA groups (R=0.08; R=0.07, respectively) were observed. Conclusions: The present results showing the lack of influence of fetal chronic hypoxia on urinary P-SEP levels offer additional data to hypothesize the possible use of urinary P-SEP measurement in neonates in daily clinical practice. Further multicenter prospective data are needed, including infants with early-onset sepsis. (© 2024 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu