[Features of lung damage in baclofen poisoning].

Autor:	Romanova OL; Russian University of People Friendship, Moscow, Russia.; Avtsyn Research Institute of Human Morphology «Petrovsky Russian Scientific Center of Surgery», Moscow, Russia., Blagonravov ML; Russian University of People Friendship, Moscow, Russia., Djuvalyakov PG; Russian University of People Friendship, Moscow, Russia.; Avtsyn Research Institute of Human Morphology «Petrovsky Russian Scientific Center of Surgery», Moscow, Russia., Barinov EK; Russian University of People Friendship, Moscow, Russia.; A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia., Ershov AV; Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation, Moscow, Russia., Kislov MA; Pirogov Russian National Research Medical University, Moscow, Russia.
Jazyk:	ruština
Zdroj:	Sudebno-meditsinskaia ekspertiza [Sud Med Ekspert] 2024; Vol. 67 (1), pp. 29-33.
DOI:	10.17116/sudmed20246701129
Abstrakt:	Objective: To reveal pathological lung changes in baclofen poisoning and to assess their dynamics. Material and Methods: The experiment included 20 mature (at age 20 weeks) male rats of Wistar line weighing 290-350 gr. The animals were divided into 3 study groups (5 rats in each) depending on experiment's duration after 85 mg/kg baclofen administration: 3, 4.5 and 24 h in the 1st, 2nd and 3rd groups, respectively. Control group consisted of 5 animals without baclofen administration. Results: A number of pathological reactions, including circulatory disorder (venular and capillary congestion, hemorrhage in interalveolar septa, alveoli, sludge) and the appearance of emphysema loci (interalveolar septa at emphysema loci are thinned), alternating with atelectases and dystelectases. The area taken up by vessels after 4.5 h. baclofen administration was statistically significantly higher than in control group, and after 24 h. - statistically significantly higher than in 4.5 h. The area with white blood cells and WBC/IAP ratio after 4.5 h of baclofen administration were statistically significantly higher than in control group after 3 and 24 h of administration. The number of white blood cells, giving PAS positive reaction, increases during baclofen administration. The complex of pathological lung changes, revealed by ourselves, has a certain dynamics. Conclusion: The data on morphological lung changes combined with results of chemical examination can be used to diagnose baclofen poisoning and to determine the time elapsed since this medicine administration.
Databáze:	MEDLINE
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