The Impact and Implications of Regenerative Medicine in Urology.

Autor:	Abuharb AI; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Alzarroug AF; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Algahtani SN; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Alghamdi HK; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Alosaimi FA; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Alsuwayna N; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU., Almughira AI; College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jan 14; Vol. 16 (1), pp. e52264. Date of Electronic Publication: 2024 Jan 14 (Print Publication: 2024).
DOI:	10.7759/cureus.52264
Abstrakt:	Urology focuses on the treatment of genitourinary disorders through therapies ranging from lifestyle changes to advanced surgeries; the field has recently incorporated robotic and minimally invasive technologies that have improved patient outcomes and reduced hospital stays and complications. However, these methods still have certain limitations. Regenerative medicine, focusing on natural repair abilities, can be an effective and safer alternative. This review aims to examine the impact of regenerative medicine in urology. We adopted a systematic review design by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. An exhaustive online literature search involving the databases PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), and Google Scholar was conducted spanning the period between January 2010 and October 2023. Data were extracted from studies on regenerative medicine in urology with a special focus on efficacy and safety. Data from 16 studies were analyzed, which showed that cell therapy, biological materials, and tissue engineering are generally used in the field of urinary diseases. The main applications include the regeneration of urinary tissue, the correction of urinary incontinence, the treatment of erectile dysfunction, the reconstruction of ureteric defects, and the formation of bladder tissue. The study findings generally lack definitive conclusions on effectiveness and safety. While our results indicate that regenerative medicine is successful on a subjective level, more clinical trials are needed to establish its effectiveness and safety. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Abuharb et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu