microRNAs in exhaled breath condensate for diagnosis of lung cancer in a resource-limited setting: a concise review.

Autor:	Rai D; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Pattnaik B; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Bangaru S; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Tak J; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Kumari J; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Verma U; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Vadala R; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Yadav G; Indian Council of Medical Research, New Delhi, India., Dhaliwal RS; Indian Council of Medical Research, New Delhi, India., Kumar S; Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India., Kumar R; Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India., Jain D; Department of Pathology, All India Institute of Medical Sciences, New Delhi, India., Luthra K; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India., Chosdol K; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India., Palanichamy JK; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India., Khan MA; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India., Surendranath A; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Mittal S; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Tiwari P; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Hadda V; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Madan K; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Agrawal A; Trivedi School of Biosciences, Ashoka University, Sonipat, India., Guleria R; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India., Mohan A; Breathomics in Respiratory Diseases Lab, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India.
Jazyk:	angličtina
Zdroj:	Breathe (Sheffield, England) [Breathe (Sheff)] 2023 Dec; Vol. 19 (4), pp. 230125. Date of Electronic Publication: 2024 Feb 13.
DOI:	10.1183/20734735.0125-2023
Abstrakt:	Lung cancer is one of the common cancers globally with high mortality and poor prognosis. Most cases of lung cancer are diagnosed at an advanced stage due to limited diagnostic resources. Screening modalities, such as sputum cytology and annual chest radiographs, have not proved sensitive enough to impact mortality. In recent years, annual low-dose computed tomography has emerged as a potential screening tool for early lung cancer detection, but it may not be a feasible option for developing countries. In this context, exhaled breath condensate (EBC) analysis has been evaluated recently as a noninvasive tool for lung cancer diagnosis. The breath biomarkers also have the advantage of differentiating various types and stages of lung cancer. Recent studies have focused more on microRNAs (miRNAs) as they play a key role in tumourigenesis by regulating the cell cycle, metastasis and angiogenesis. In this review, we have consolidated the current published literature suggesting the utility of miRNAs in EBC for the detection of lung cancer. Competing Interests: Conflict of interest: The authors have no conflicts of interest or disclosures. (Copyright ©ERS 2024.)
Databáze:	MEDLINE
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