Polyether ionophore resistance in a one health perspective.
| Autor: | Frederiksen RF; Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway., Slettemeås JS; Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway., Granstad S; Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway., Lagesen K; Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway., Pikkemaat MG; Wageningen Food Safety Research, Wageningen University and Research, Wageningen, Netherlands., Urdahl AM; Department of Animal Health, Welfare and Food Safety, Norwegian Veterinary Institute, Ås, Norway., Simm R; Department of Biosciences, University of Oslo, Oslo, Norway. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in microbiology [Front Microbiol] 2024 Jan 29; Vol. 15, pp. 1347490. Date of Electronic Publication: 2024 Jan 29 (Print Publication: 2024). |
| DOI: | 10.3389/fmicb.2024.1347490 |
| Abstrakt: | Antimicrobial resistance is a major threat to human health and must be approached from a One Health perspective. Use of antimicrobials in animal husbandry can lead to dissemination and persistence of resistance in human pathogens. Polyether ionophores (PIs) have antimicrobial activities and are among the most extensively used feed additives for major production animals. Recent discoveries of genetically encoded PI resistance mechanisms and co-localization of resistance mechanisms against PIs and antimicrobials used in human medicine on transferrable plasmids, have raised concerns that use of PIs as feed additives bear potential risks for human health. This review summarizes the current knowledge on PI resistance and discusses the potential consequences of PI-usage as feed additives in a One Health perspective. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Frederiksen, Slettemeås, Granstad, Lagesen, Pikkemaat, Urdahl and Simm.) |
| Databáze: | MEDLINE |
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