Eating disorders in narcolepsy type 1: Evidence from a cross-sectional Italian study.

Autor: Baldini V; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Venezia N; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Iriti A; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Quattrocchi S; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Zenesini C; IRCCS Istituto Delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy., Biscarini F; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Atti AR; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Menchetti M; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Franceschini C; Department of Medicine and Surgery, University of Parma, Parma, Italy., Varallo G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., De Ronchi D; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy., Plazzi G; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.; IRCCS Istituto Delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy., Pizza F; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.; IRCCS Istituto Delle Scienze Neurologiche di Bologna (ISNB), Bologna, Italy.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2024 Oct; Vol. 33 (5), pp. e14150. Date of Electronic Publication: 2024 Feb 13.
DOI: 10.1111/jsr.14150
Abstrakt: Narcolepsy type 1 is a chronic central disorder of hypersomnolence, and it is frequently accompanied by overweight, but the association between narcolepsy type 1 and eating disorders is controversial. Our study aims to compare patients with narcolepsy type 1 and controls on the symptomatology of eating disorders and to evaluate the association between clinical factors. This is a cross-sectional study, with consecutive recruitment of patients with narcolepsy type 1 attending the Outpatient Clinic for Narcolepsy at the IRCCS Istituto delle Scienze Neurologiche di Bologna (Italy) for routine follow-up visits. Healthy subjects from general populations were recruited as controls. Patients underwent a questionnaire-based assessment using the Eating Disorder Examination Questionnaire (EDE-Q), Binge Eating Scale (BES), Italian Night Eating Questionnaire (I-NEQ), Epworth Sleepiness Scale (ESS), and Narcolepsy Severity Scale (NSS). One hundred and thirty-eight patients with narcolepsy type 1 and 162 controls were enrolled. This study showed that individuals with narcolepsy type 1 reported higher scores on the EDE-Q, I-NEQ, and a higher body mass index (BMI) than the controls. The logistic regression analysis results, with EDE-Q positivity as a dependent variable, demonstrate a significant association with antidepressant drugs, female sex, and the use of sodium oxybate. We found an association between antidepressant drug consumption, the NSS total score, and female sex with BES positivity as the dependent variable. The logistic regression analysis for I-NEQ positivity found an association with antidepressant drug use. This study shows that patients with narcolepsy type 1 frequently present with comorbid eating disorder symptomatology, mainly night eating syndrome. Investigating the possible presence of eating disorders symptomatology through questionnaires is fundamental during the assessment of patients with narcolepsy type 1.
(© 2024 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
Databáze: MEDLINE
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