Therapeutic Potential of Green Synthesized Silver Nanoparticles for Promoting Wound-Healing Process in Diabetic Mice.

Autor: Iqbal R; Department of Zoology, Government College University Lahore, Lahore, Pakistan. riffatiqbal@gcu.edu.pk., Asghar A; Department of Zoology, Government College University Lahore, Lahore, Pakistan., Habib A; Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China. 20110700169@fudan.edu.cn., Ali S; Department of Chemistry, Government College University Lahore, Lahore, Pakistan., Zahra S; Department of Zoology, Government College University Lahore, Lahore, Pakistan., Hussain MI; Riphah International University, Lahore, Pakistan., Ahsan AB; Al-Aleem Medical College Lahore, Lahore, Pakistan., Liang Y; Laboratory of Molecular Immunology, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200433, People's Republic of China.
Jazyk: angličtina
Zdroj: Biological trace element research [Biol Trace Elem Res] 2024 Dec; Vol. 202 (12), pp. 5545-5555. Date of Electronic Publication: 2024 Feb 14.
DOI: 10.1007/s12011-024-04094-8
Abstrakt: Diabetes is a serious metabolic disorder characterized by abnormal glucose levels in the body. Delayed wound healing is a severe diabetes complication. Nanotechnology represents the latest advancement in treating diabetic wounds through nanoparticles (NPs). In this study, silver nanoparticles (AgNPs) were synthesized using a green method involving cucumber pulp extract. The synthesis was confirmed using techniques including ultraviolet-visible spectrophotometry (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX). To evaluate wound-healing properties, mouse models were utilized with wounds induced by excision on the dorsal surface. An ointment containing silver nanoparticles was applied to assess its healing potential. Additionally, antibacterial and antioxidant activities were examined using agar well diffusion and DPPH scavenging methods, respectively. The results demonstrated that the ointment prepared with green synthesized AgNPs effectively healed the wounds within 15 days, while also exhibiting antibacterial and antioxidant properties. Therefore, it can be concluded that due to its efficacy in biological activities, silver nanoparticles can be employed in the treatment of diabetic wounds.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
Externí odkaz: