Cancer of unknown primary and the «seed and soil» hypothesis.

Autor: Zolotykh MA; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: MAZolotykh@kpfu.ru., Mingazova LA; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: LeyAMingazova@kpfu.ru., Filina YV; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: JVFilina@kpfu.ru., Blatt NL; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: NLBlatt@kpfu.ru., Nesterova AI; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation; Republican Clinical Oncology Dispensary named after prof. M.Z.Sigal, Kazan, Russian Federation. Electronic address: AlfIKhasanova@kpfu.ru., Sabirov AG; Republican Clinical Oncology Dispensary named after prof. M.Z.Sigal, Kazan, Russian Federation., Rizvanov AA; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: Albert.Rizvanov@kpfu.ru., Miftakhova RR; Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russian Federation. Electronic address: ReRMiftahova@kpfu.ru.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Apr; Vol. 196, pp. 104297. Date of Electronic Publication: 2024 Feb 11.
DOI: 10.1016/j.critrevonc.2024.104297
Abstrakt: The worldwide incidence rate of cancer of unknown primary (CUP) reaches 5% (Kang et al, 2021; Lee, Sanoff, 2020; Yang et al, 2022). CUP has an alarmingly high mortality rate, with 84% of patients succumbing within the first year following diagnosis (Registration and Service, 2018). Under normal circumstances, tumor cell metastasis follows the «seed and soil» hypothesis, displaying a tissue-specific pattern of cancer cell homing behavior based on the microenvironment composition of secondary organs. In this study, we questioned whether seed and soil concept applies to CUP, and whether the pattern of tumor and metastasis manifestations for cancer of known primary (CKP) can be used to inform diagnostic strategies for CUP. We compared data from metastatic and primary CUP foci to the metastasis patterns observed in CKP. Furthermore, we evaluated several techniques for identifying the tissue-of-origin (TOO) in CUP profiling, including DNA, RNA, and epigenetic TOO techniques.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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