Parahydrogen-Induced 13 C Hyperpolarizer Using a Flow Guide for Magnetic Field Cycling to Evoke 1 H- 13 C Spin Order Transfer Toward Metabolic MRI.
| Autor: | Sawami K, Naganuma T, Yabe H, Taki T, Stewart NJ, Uchio Y, Takeda N, Hatae N, Hashimoto T, Hirata H, Matsumoto S |
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| Jazyk: | angličtina |
| Zdroj: | IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2024 Jul; Vol. 71 (7), pp. 2224-2231. Date of Electronic Publication: 2024 Jun 19. |
| DOI: | 10.1109/TBME.2024.3365195 |
| Abstrakt: | Objective: The pair-wise addition of parahydrogen, the singlet form of molecular hydrogen, to unsaturated precursors evokes the hyperpolarization of two parahydrogen-derived 1 H nuclear spins through a process known as parahydrogen-induced polarization (PHIP). Subsequent spin order transfer (SOT) from the 1 H to the surrounding 13 C nuclear spins via magnetic field cycling (MFC) results in substantial signal enhancement in 13 C magnetic resonance imaging (MRI). Here, we report the development of a unique PHIP 13 C hyperpolarizer system using a flow guide for MFC. Methods: The optimal MFC scheme for 1 H to 13 C spin order transfer was quantum-chemically simulated using the J-coupling values of 13 C-labeled metabolic tracers. The flow guide system was three-dimensionally designed based on the simulated MFC scheme and pre-measured magnetic field distribution in a zero-field chamber. Results: The system efficiently transfers the spin order of hyperpolarized 1 H to a particular 13 C spin when the parahydrogenated tracer passes through the flow guide at a designated flow rate. The 13 C MRI signal is enhanced more than 40,000 times in 13 C-labeled pyruvate and fumarate, compared to the thermal equilibrium level at 1.5 T, was achieved for conducting in vivo metabolic MRI of mice. Conclusion: A fully automated PHIP-based 13 C polarizer was developed using a unique flow guide to conduct the MFC for 1 H to 13 C SOT. Significance: The PHIP hyperpolarizer with a flow guide can conduct efficient 1 H- 13 C SOT without a MFC magnetic field sweep system and offers a cost-effective alternative to conventional dynamic nuclear polarization. |
| Databáze: | MEDLINE |
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