Prunes preserve cortical density and estimated strength of the tibia in a 12-month randomized controlled trial in postmenopausal women: The Prune Study.

Autor: Koltun KJ; Department of Kinesiology, Pennsylvania State University, 104 Noll Laboratory, University Park, PA, 16802, USA., Strock NCA; Department of Kinesiology, Pennsylvania State University, 104 Noll Laboratory, University Park, PA, 16802, USA., Weaver C; School of Exercise and Nutritional Sciences, San Diego State University, San Diego, USA., Lee H; Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, USA., Williams NI; Department of Kinesiology, Pennsylvania State University, 104 Noll Laboratory, University Park, PA, 16802, USA., Rogers CJ; Intercollege Graduate Degree Program in Integrative and Biomedical Physiology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, USA., Damani J; Intercollege Graduate Degree Program in Integrative and Biomedical Physiology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, USA., Ferruzzi MG; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, USA., Nakatsu CH; Department of Agronomy, Purdue University, West Lafayette, USA., De Souza MJ; Department of Kinesiology, Pennsylvania State University, 104 Noll Laboratory, University Park, PA, 16802, USA. mjd34@psu.edu.
Jazyk: angličtina
Zdroj: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [Osteoporos Int] 2024 May; Vol. 35 (5), pp. 863-875. Date of Electronic Publication: 2024 Feb 13.
DOI: 10.1007/s00198-024-07031-6
Abstrakt: Non-pharmacological therapies, such as whole-food interventions, are gaining interest as potential approaches to prevent and/or treat low bone mineral density (BMD) in postmenopausal women. Previously, prune consumption preserved two-dimensional BMD at the total hip. Here we demonstrate that prune consumption preserved three-dimensional BMD and estimated strength at the tibia.
Purpose: Dietary consumption of prunes has favorable impacts on areal bone mineral density (aBMD); however, more research is necessary to understand the influence on volumetric BMD (vBMD), bone geometry, and estimated bone strength.
Methods: This investigation was a single center, parallel arm 12-month randomized controlled trial (RCT; NCT02822378) to evaluate the effects of 50 g and 100 g of prunes vs. a Control group on vBMD, bone geometry, and estimated strength of the radius and tibia via peripheral quantitative computed tomography (pQCT) in postmenopausal women. Women (age 62.1 ± 5.0yrs) were randomized into Control (n = 78), 50 g Prune (n = 79), or 100 g Prune (n = 78) groups. General linear mixed effects (LME) modeling was used to assess changes over time and percent change from baseline was compared between groups.
Results: The most notable effects were observed at the 14% diaphyseal tibia in the Pooled (50 g + 100 g) Prune group, in which group × time interactions were observed for cortical vBMD (p = 0.012) and estimated bone strength (SSI; p = 0.024); all of which decreased in the Control vs. no change in the Pooled Prune group from baseline to 12 months/post.
Conclusion: Prune consumption for 12 months preserved cortical bone structure and estimated bone strength at the weight-bearing tibia in postmenopausal women.
(© 2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.)
Databáze: MEDLINE
Externí odkaz: