Cytokines (IL1β, IL6, TNFα) and serum cortisol levels may not constitute reliable biomarkers to identify individuals with post-acute sequelae of COVID-19.

Autor:	Fleischer M; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Szepanowski F; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Mausberg AK; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Asan L; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Uslar E; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Zwanziger D; Department of Endocrinology, Diabetes and Metabolism, Clinical Chemistry - Division of Laboratory Research, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Volbracht L; Central Laboratory, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Stettner M; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University Duisburg-Essen, Essen, Germany., Kleinschnitz C; Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, Hufelandstr. 55, Essen 45147, Germany.
Jazyk:	angličtina
Zdroj:	Therapeutic advances in neurological disorders [Ther Adv Neurol Disord] 2024 Feb 12; Vol. 17, pp. 17562864241229567. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
DOI:	10.1177/17562864241229567
Abstrakt:	Background: Post-acute sequelae of COVID-19 (PASC) comprise a broad spectrum of symptoms such as fatigue, general weakness, compromised attention and sleep or anxiety disorders. PASC represents a medical and socio-economic challenge. Objectives: Our study evaluated cytokines (IL-1β, IL-6 and TNFα) and cortisol levels in a cohort of typical patients with PASC, suffering concentration problems, fatigue and difficulties finding words. Design: This was a prospective cohort study. Four groups were analysed and compared: those who had never contracted SARS-CoV-2 ( n  = 13), infected but had no PASC ( n  = 34), infected with former PASC that resolved ( n  = 40) and patients with ongoing PASC after infection ( n  = 91). Methods: Cytokine and cortisol serum levels were determined in patients' blood samples. Results: Cytokine levels of IL-1β, IL-6, TNFα and cortisol levels did not differ between groups analysed. Conclusion: This may indicate a non-organic/psychosomatic genesis of PASC; further studies are needed to elucidate the underlying causes of PACS, and non-organic causes should not be overlooked. Competing Interests: MF, LA, EU, AKM, FS, LV, DZ, CK and MS declare that they have no competing interest in connection with the submitted material. (© The Author(s), 2024.)
Databáze:	MEDLINE
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