Assessing the Impact of Genratest on Women With Recurrent Implantation Failure: A Single-Center Study.

Autor:	Tran HP; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Ly LT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Do VN; Medical Genetics Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Hoang TT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Tran TT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Le HN; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Nguyen PT; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Nguyen NA; Infertility Department, Hung Vuong Hospital, Ho Chi Minh, VNM., Huynh TN; Obstetrics and Gynaecology Department, Pham Ngoc Thach University of Medicine, Ho Chi Minh, VNM.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Jan 14; Vol. 16 (1), pp. e52256. Date of Electronic Publication: 2024 Jan 14 (Print Publication: 2024).
DOI:	10.7759/cureus.52256
Abstrakt:	Objective Recurrent implantation failure (RIF) is a significant challenge in assisted reproduction. Genratest has emerged as a potential tool to identify the displaced window of implantation (WOI). This study aimed to evaluate the impact of this test on the pregnancy outcomes of RIF patients. Methods A retrospective analysis was conducted on 143 RIF patients who were categorized into two groups: the personalized embryo transfer (pET, n=69) group and standard embryo transfer (sET, n=74) group. The main measured outcomes were clinical pregnancy, ongoing pregnancy, miscarriage, and live birth rates. Results Genratest effectively diagnoses the displaced WOI in 90% of RIF patients. The pET group exhibited a higher rate of clinical pregnancy (n=36/69, 52.2%) compared to the sET group (n=35/74, 47.3%), but this difference was not statistically significant (p=0.679). Ongoing pregnancy rates were comparable between the pET (n=28/69, 40.6%) and the sET (n=30/74, 40.5%) groups (p=0.996). Live birth rates showed no statistically significant difference between the two groups (n=26/69, 37.7% versus n=22/74, 29.7%, p=0.407). Miscarriage rates were similar in both groups (n=9/69, 13% versus n=11/74, 14.9%, p=0.942). Conclusions pET based on the results of the Genratest did not show a significant improvement in pregnancy outcomes, including clinical pregnancy, ongoing pregnancy, live birth, or miscarriage rates. Further research is needed to identify the role of Genratest in RIF patients. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Tran et al.)
Databáze:	MEDLINE
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