Prostaglandin E 2 /Leukotriene B 4 balance and viral load in distinct clinical stages of COVID-19: A cross-sectional study.

Autor: Gadelha LR; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Costa MJB; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Abreu JPA; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Venancio LPR; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Fabres-Klein MH; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Klein RC; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Lima JB; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil., Araújo-Santos T; Universidade Federal do Oeste da Bahia (UFOB), Núcleo de Estudos de Agentes Infecciosos e Vetores (NAIVE), Centro das Ciências Biológicas e da Saúde, Barreiras, BA, Brazil. Electronic address: theo.santos@ufob.edu.br.
Jazyk: angličtina
Zdroj: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Jun; Vol. 172, pp. 106820. Date of Electronic Publication: 2024 Feb 10.
DOI: 10.1016/j.prostaglandins.2024.106820
Abstrakt: Background: Prostaglandin E 2 (PGE 2 ) and leukotriene B 4 (LTB 4 ) are eicosanoids involved in modulation of the antiviral immune response. Recent studies have identified increased levels of several eicosanoids in the plasma and bronchoalveolar lavage of patients with coronavirus disease (COVID-19). This study investigated correlations between plasma levels of PGE 2 and LTB 4 and clinical severity of COVID-19.
Methods: This cross-sectional study involved non-infected (n = 10) individuals and COVID-19 patients classified as cured (n = 13), oligosymptomatic (n = 29), severe (n = 15) or deceased (n = 11). Levels of D-dimer a, known COVID-19 severity marker, PGE 2 and LTB 4 were measured by ELISAs and data were analysed with respect to viral load.
Results: PGE 2 plasma levels were decreased in COVID-19 patients compared to the non-infected group. Changes in PGE 2 and LTB 4 levels did not correlate with any particular clinical presentations of COVID-19. However, LTB 4 was related to decreased SARS-CoV-2 burden in patients, suggesting that only LTB 4 is associated with control of viral load.
Conclusions: Our data indicate that PGE 2 /LTB 4 plasma levels are not associated with COVID-19 clinical severity. Hospitalized patients with COVID-19 are treated with corticosteroids, which may influence the observed eicosanoid imbalance. Additional analyses are required to fully understand the participation of PGE 2 receptors in the pathophysiology of COVID-19.
Competing Interests: Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: