The cell cycle revisited: DNA replication past S phase preserves genome integrity.

Autor: Bournaka S; Department of General Biology, Medical School, University of Patras, Patras 26504, Greece., Badra-Fajardo N; Department of General Biology, Medical School, University of Patras, Patras 26504, Greece., Arbi M; Department of General Biology, Medical School, University of Patras, Patras 26504, Greece., Taraviras S; Department of Physiology, Medical School, University of Patras, Patras 26504, Greece., Lygerou Z; Department of General Biology, Medical School, University of Patras, Patras 26504, Greece. Electronic address: lygerou@upatras.gr.
Jazyk: angličtina
Zdroj: Seminars in cancer biology [Semin Cancer Biol] 2024 Feb; Vol. 99, pp. 45-55. Date of Electronic Publication: 2024 Feb 10.
DOI: 10.1016/j.semcancer.2024.02.002
Abstrakt: Accurate and complete DNA duplication is critical for maintaining genome integrity. Multiple mechanisms regulate when and where DNA replication takes place, to ensure that the entire genome is duplicated once and only once per cell cycle. Although the bulk of the genome is copied during the S phase of the cell cycle, increasing evidence suggests that parts of the genome are replicated in G2 or mitosis, in a last attempt to secure that daughter cells inherit an accurate copy of parental DNA. Remaining unreplicated gaps may be passed down to progeny and replicated in the next G1 or S phase. These findings challenge the long-established view that genome duplication occurs strictly during the S phase, bridging DNA replication to DNA repair and providing novel therapeutic strategies for cancer treatment.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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