Disease-free survival and response to therapy of clinically node- negative Papillary Thyroid Cancer treated without central neck dissection: Retrospective study of 321 patients.

Autor: Ruiz-García C; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Rodrigáñez Riesco L; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Mateos-Serrano B; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Bernáldez Millán R; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Del Palacio Muñoz AJ; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Gavilán J; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain., Parra Ramírez P; Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain., Martín-Rojas Marcos P; Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain., Lisbona Catalán A; Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain., Lecumberri B; Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain., Álvarez-Escolá C; Endocrinology and Nutrition Department, Hospital Universitario La Paz, Madrid, Spain., Castro A; Otorhinolaryngology Department, Hospital Universitario La Paz, Madrid, Spain. Electronic address: alejandro.castroc@salud.madrid.org.
Jazyk: angličtina
Zdroj: Acta otorrinolaringologica espanola [Acta Otorrinolaringol Esp (Engl Ed)] 2024 Jul-Aug; Vol. 75 (4), pp. 224-230. Date of Electronic Publication: 2024 Feb 10.
DOI: 10.1016/j.otoeng.2024.01.006
Abstrakt: Background and Objective: Nodal metastases in the central compartment are frequent in papillary thyroid cancer (PTC). However, they are mostly micrometastases with no impact on survival and their relevance on the risk of locoregional relapse is controversial. There is no consensus regarding optimal management of the central neck in patients with PTC cN0. In our center, we do not perform prophylactic central neck dissection (pCND). The objective of this study is to review our long-term results and compare them with the most recent literature.
Patients and Methods: Retrospective review of patients with PTC who underwent total thyroidectomy (TT) without CND between 2005 and 2017. Primary result was disease-free survival in the neck (DFS).
Results: 321 patients were identified, mostly T1-T2 tumors (94.1%). Median follow-up was 90 months. DFS in the central compartment was excellent (96.1% at 10 year's follow-up). 19 patients had cervical recurrence, of which 15 underwent salvage surgery. On their last visit, including salvage surgery when appropriate, 77% of patients had excellent response, 18.7% had indeterminate response, 3.1% had biochemically incomplete response and 1.2% had morphologically incomplete response. Recurrent laryngeal nerve (RLN) paralysis after TT was transient in 4.7% of patients and permanent in 0.9% of patients. There were no RLN paralysis after salvage surgery. Permanent hypoparathyroidism occurred in 3.4% of patients. Only one patient had hypoparathyroidism after salvage surgery and it was permanent.
Conclusions: Based on long-term results and low rate of complications associated with salvage surgery in our experience, we consider routine pCND is not justified.
(Copyright © 2024 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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