A comparison of Bartonella henselae infection in immunocompetent and immunocompromised mice.

Autor: Bullard RL; Division of Immunology, Tulane University, Covington, Louisiana, United States of America., Cheslock M; Division of Immunology, Tulane University, Covington, Louisiana, United States of America., Goud Gadila SK; Division of Immunology, Tulane University, Covington, Louisiana, United States of America., Maggi RG; Intracellular Pathogens Research Laboratory, Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Breitschwerdt EB; Intracellular Pathogens Research Laboratory, Department of Clinical Sciences, Comparative Medicine Institute, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States of America., Saied AA; Division of Comparative Pathology, Tulane National Primate Research Center, Tulane University, Covington, Louisiana, United States of America., Embers ME; Division of Immunology, Tulane University, Covington, Louisiana, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 12; Vol. 19 (2), pp. e0297280. Date of Electronic Publication: 2024 Feb 12 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0297280
Abstrakt: Bartonellosis refers to disease caused by the Bartonella genus of bacteria. The breadth of disease manifestations associated with Bartonella is currently expanding and includes regional lymphadenopathy, rheumatic, ocular, and neurological disorders. The dearth of knowledge regarding diagnosis, treatment and pathogenesis of this disease can be partially attributed to the lack of a reliable small animal model for the disease. For this study, Bartonella henselae, the most common species associated with human disease, was injected into Swiss Webster (SW) mice. When the outcome indicated that productive infection did not occur, SCID/Beige (immune compromised) mice were inoculated. While SW mice may potentially harbor an acute infection, less than 10 days in length, the SCID/Beige model provided a sustained infection lasting up to 30-days. These data indicate that SCID/Beige mice can provide a model to study Bartonella infection, therapeutics, and vector dynamics in the future.
Competing Interests: Edward B. Breitschwerdt, DVM holds U.S. Patent No. 7115385; Media and Methods for cultivation of microorganisms, which was issued October 3, 2006. He is a co‐founder, shareholder and Chief Scientific Officer for Galaxy Diagnostics, a company that provides advanced diagnostic testing for the detection of Bartonella species infections. All other authors declare no potential conflicts of interest.
(Copyright: © 2024 Bullard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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