Association of Systemic Markers of Inflammation with Signs and Symptoms of Dry Eye Disease and Sjogren's Syndrome in the Dry Eye Assessment and Management (DREAM©) Study.
| Autor: | Hashemi MH; University of Tennessee Health Sciences Center, Memphis, TN, USA., Ambrus JL Jr; Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA., Shukla AA; Immco Diagnostics, Buffalo, NY, USA., Zhu D; Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Ying GS; Department of Ophthalmology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Asbell PA; University of Memphis, Memphis, TN, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Current eye research [Curr Eye Res] 2024 Jun; Vol. 49 (6), pp. 574-581. Date of Electronic Publication: 2024 Feb 12. |
| DOI: | 10.1080/02713683.2024.2312937 |
| Abstrakt: | Purpose: To evaluate the possible role of systemic inflammation in dry eye disease (DED) via systemic inflammatory marker associations with DED signs and symptoms, and an analysis of a subgroup with Sjogren's Syndrome (SS). Methods: Participant serums were analyzed using line immunoassays (LIAs) for the presence of antibodies against 34 systemic inflammatory markers. Using the 2012 American College of Rheumatology definition, the 481 participants were categorized into group 1 (SS; n = 52), group 2 (autoimmune disease not including SS; n = 66), or group 3 (control, i.e. no autoimmune disease; n = 363). Results: 3 markers were positive in ≥10% of participants: Ro52 (19.3%), Scl-70 (15.0%), CN-1A (14.2%). 2 markers were positively associated with symptoms: PM-Scl100 ( p = 0.02), Sm ( p = 0.009). 5 markers were positively associated with signs: U2SnRNP A', Ro52, La, DNA, Ro60. SS participants showed significantly higher positivity for 4 markers compared to participants with no autoimmune disease: PL-7 ( p = 0.02), Ro52 ( p < 0.0001), La ( p < 0.0001), Ro60 ( p < 0.0001). SS participants showed significantly higher positivity for 3 markers compared to participants with another autoimmune disease: Ro52 ( p < 0.0001), La ( p = 0.002), Ro60 ( p < 0.0001). Conclusions: This study did not show evidence of significant systemic inflammation in participants with moderate-to-severe DED, based on the markers tested. PM-Scl100 and Sm may be associated with more severe DED symptoms. U2SnRNP A', Ro52, La, DNA, and Ro60 may be associated with more severe ocular surface disease. Ro52 and PL-7 may be diagnostic markers for SS. Future research evaluating these relationships and their clinical significance is needed. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|