Severe Clozapine-Induced Agranulocytosis, Pharmacodynamic Synergism, and Lithium Promyelocytic Effects in Granulocyte Colony-Stimulating Factor (G-CSF) Resistance or Delayed Response: A Case Report.
| Autor: | Owusu-Antwi P; Psychiatry, Richmond University Medical Center, Staten Island, USA., Appiah-Kubi E; Internal Medicine, Allegheny Health Network, Pittsburgh, USA., Kinfe M; Psychiatry, American University of Antigua, Staten Island, USA., Gbinigie S; Psychiatry, St. George's University School of Medicine, St. George's, GRD., Sarwal A; Psychiatry, Richmond University Medical Center, Staten Island, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Jan 11; Vol. 16 (1), pp. e52092. Date of Electronic Publication: 2024 Jan 11 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.52092 |
| Abstrakt: | Clozapine-induced agranulocytosis is documented in multiple studies, but there is limited literature on treatment-resistant agranulocytosis, the synergistic effect of multiple agranulocytosis-inducing drugs, and lithium's promyelocytic effects. This case highlights these gaps by discussing a patient with an absolute neutrophil count of zero while being treated with Depakote, Haldol, and clozapine. This case proposes more research on lithium's promyelocytic effects, especially in patients who are unresponsive or have a delayed response to discontinuing offending agents and granulocyte colony-stimulating factor (G-CSF). Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Owusu-Antwi et al.) |
| Databáze: | MEDLINE |
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