Autor: |
Ribeiro-Júnior KAL; Institute of Chemistry and Biotechnology, Federal University of Alagoas A. C. Simões Campus, Maceió, AL, Brazil., Souza da Silva SA; Laboratory of Medicinal Chemistry, Pharmaceutical Sciences Institute, Federal University of Alagoas A. C. Simões Campus, Maceió, AL, Brazil., Araújo-Júnior JX; Laboratory of Medicinal Chemistry, Pharmaceutical Sciences Institute, Federal University of Alagoas A. C. Simões Campus, Maceió, AL, Brazil., Costa JGD; Embrapa Food and Territories, Embrapa, Maceió, AL, Brazil., Fonseca Goulart H; Agricultural Sciences Centre, Federal University of Alagoas, Rio Largo-AL, Brazil., Bernardo VB; Institute of Chemistry and Biotechnology, Federal University of Alagoas A. C. Simões Campus, Maceió, AL, Brazil., Silva MSD; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, João Pessoa, Brazil., Tavares JF; Postgraduate Program in Natural and Synthetic Bioactive Products, Federal University of Paraiba, João Pessoa, Brazil., Santana AEG; Institute of Chemistry and Biotechnology, Federal University of Alagoas A. C. Simões Campus, Maceió, AL, Brazil.; Agricultural Sciences Centre, Federal University of Alagoas, Rio Largo-AL, Brazil. |
Abstrakt: |
Mosquitoes of the Aedes genus are responsible for transmitting many vector-borne viral diseases worldwide. Hundreds of thousands of people die annually from vector-borne diseases, including West Nile fever, dengue, tick-borne diseases, yellow fever, chikungunya, Rift Valley fever, and Zika. Billions of people are at the risk of infection on all continents, which is a cause of international concern. Therefore, new vector-control methods are essential for mitigating these illnesses. The bioactive hydrocarbons isolated from Xylopia langsdorfiana St. Hilaire & Tulasne are trachylobanes, a rare class of diterpenes found in the n -hexane fraction of the stem and leaf ethanolic extracts. These were tested against Ae. aegypti fourth-instar larvae over 48 h of exposure, with LC 50 values ranging from 19.84 to 72.9 µg/mL, comparable to that of the positive control. The findings highlight the potential of Xylopia langsdorfiana St. Hilaire & Tulasne metabolites for controlling the main vectors of arthropod-borne viruses. |