| Autor: |
Leite FG; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil., Sampaio CF; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil., Cardoso Pires JA; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil., de Oliveira DP; School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT‑DATREM), Institute of Chemistry, São Paulo State University (UNESP), Araraquara, Brazil., Dorta DJ; Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Departamento de Química, Universidade de São Paulo, São Paulo, Brazil.; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT‑DATREM), Institute of Chemistry, São Paulo State University (UNESP), Araraquara, Brazil. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes [J Environ Sci Health B] 2024; Vol. 59 (4), pp. 142-151. Date of Electronic Publication: 2024 Feb 11. |
| DOI: |
10.1080/03601234.2024.2312786 |
| Abstrakt: |
Fungicides are specifically used for controlling fungal infections. Strobilurins, a class of fungicides originating from the mushroom Strobilurus tenacellus , act on the fungal mitochondrial respiratory chain, interrupting the ATP cycle and causing oxidative stress. Although strobilurins are little soluble in water, they have been detected in water samples (such as rainwater and drinking water), indoor dust, and sediments, and they can bioaccumulate in aquatic organisms. Strobilurins are usually absorbed orally and are mainly eliminated via the bile/fecal route and urine, but information about their metabolites is lacking. Strobilurins have low mammalian toxicity; however, they exert severe toxic effects on aquatic organisms. Mitochondrial dysfunction and oxidative stress are the main mechanisms related to the genotoxic damage elicited by toxic compounds, such as strobilurins. These mechanisms alter genes and cause other dysfunctions, including hormonal, cardiac, neurological, and immunological impairment. Despite limitations, we have been able to compile literature information about strobilurins. Many studies have dealt with their toxic effects, but further investigations are needed to clarify their cellular and underlying mechanisms, which will help to find ways to minimize the harmful effects of these compounds. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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