The design and characterisation of sinusoidal toolpaths using sub-zero bioprinting of polyvinyl alcohol.

Autor: Gale L; Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK., Panieraki A; Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK., Mahmoodi N; Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK., Crolla JP; Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK., Thomas-Seale LEJ; Department of Mechanical Engineering, School of Engineering, University of Birmingham, UK. Electronic address: l.e.j.thomas-seale@bham.ac.uk.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Apr; Vol. 152, pp. 106402. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1016/j.jmbbm.2024.106402
Abstrakt: Sub-zero (°C) additive manufacturing (AM) systems present a promising solution for the fabrication of hydrogel structures with complex external geometry or a heterogeneous internal structure. Polyvinyl alcohol cryogels (PVA-C) are promising tissue-mimicking materials, with mechanical properties that can be designed to satisfy a wide variety of soft tissues. However, the design of more complex mechanical properties into additively manufactured PVA-C samples, which can be enabled using the toolpath, is a largely unstudied area. This research project will investigate the effect of toolpath variation on the elastic and viscoelastic properties of PVA-C samples fabricated using a sinusoidal toolpath. Samples were fabricated using parametric variation of a sinusoidal toolpath, whilst retaining the same overall cross-sectional area, using a sub-zero AM system. To mechanically characterise the samples, they were tested under tension in uniaxial ramp tests, and through dynamic mechanical analysis (DMA). The elastic and viscoelastic moduli of the samples are presented. No correlations between the parametric variation of the design and the Young's modulus were observed. Analysis of the data shows high intra-sample repeatability, demonstrated robust testing protocols, and variable inter-sample repeatability, indicating differences in the printability and consistency of fabrication between sample sets. DMA of the wavelength samples, show a frequency-dependent loss moduli. The storage modulus demonstrates frequency independence, and a large increase in magnitude as the sample increases to 3 wavelengths.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: